NEW DELIVERY SYSTEMS FOR ANTISENSE PEPTIDE NUCLEIC ACIDS (original) (raw)

This study explores novel delivery systems for peptide nucleic acids (PNAs), emphasizing their potential to inhibit inflammatory processes by targeting macrophages. The paper details three strategies: the use of a hydrophobic peptide linked to PNAs, polymeric core-shell microspheres, and red blood cells loaded with PNAs. Results indicate significant inhibition of key inflammatory enzymes (iNOS and COX-2) in macrophages, showcasing the efficacy of these delivery systems while addressing PNAs' low cellular permeability.