Antibody-targeted polymer-bound drugs (original) (raw)

This research introduces a new generation of antibody-targeted immunosuppressive (cyclosporin A) and cytostatic (doxorubicin) drugs designed for effective in vitro and in vivo applications. The conjugation of these drugs with a targeting anti-Thy 1.2 antibody via stable chemical bonds in a water-soluble synthetic polymer enhances their pharmacological activity while overcoming resistance seen with free doxorubicin. Additionally, the study covers the construction of chimeric single chain antibodies linked to a receptor for treating metastatic renal cancer, demonstrating the functional expression and efficacy of these constructs in lymphocytes against renal cell carcinoma.