Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia (original) (raw)
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
Marc Oshiro
Journal of Clinical Investigation, 2001
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STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells
Leena Kainulainen
2022
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STAT3 and STAT5B Mutations in T/NK-Cell Chronic Lymphoproliferative Disorders of Large Granular Lymphocytes (LGL): Association with Disease Features
Alberto Orfao
Cancers, 2020
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Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity
Olaf Neth
Clinical Immunology, 2020
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Clinical Relevance of Sensitive and Quantitative STAT3 Mutation Analysis Using Next-Generation Sequencing in T-Cell Large Granular Lymphocytic Leukemia
Michael Møller, Martin Larsen
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Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia
M. Facco
Blood, 2013
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STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model
Jessica zucman-rossi
Haematologica, 2013
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Stat3 Activates the Receptor Tyrosine Kinase Like Orphan Receptor-1 Gene in Chronic Lymphocytic Leukemia Cells
Ping Li, Zeev Estrov
PLoS ONE, 2010
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Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Stephen Kingsmore, Darrell Dinwiddie
Blood, 2015
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Distinct mutations at the same positions of STAT3 cause either loss or gain of function
Ofer Zimmerman
The Journal of allergy and clinical immunology, 2016
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STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression
Robert Ohgami
Haematologica, 2014
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STAT3 Dysregulation in Mature T and NK Cell Lymphomas
Kenneth B Hymes
Cancers, 2019
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STAT signaling in the pathogenesis and treatment of leukemias
Sudipta Mahajan
2000
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Identification of a STAT5 Target Gene, Dpf3, Provides Novel Insights in Chronic Lymphocytic Leukemia
Georgia Papachristopoulou
PLoS ONE, 2013
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Constitutively active STAT6 predisposes toward a lymphoproliferative disorder
SARITA SEHRA
2007
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Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma
Niels Ødum
The Journal of Immunology, 2002
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Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment
Thomas Loughran
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 2012
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High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
Andrea Binatti
Blood, 2016
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Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
luca trotta, Kaarina Heiskanen, Mikko Seppänen
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Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma
Hesham Amin
Clinical cancer research : an official journal of the American Association for Cancer Research, 2003
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Role of STAT3 in Transformation and Drug Resistance in CML
Joel Tolentino Jr.
Frontiers in Oncology, 2012
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TYK2-STAT1-BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
Alejandro Gutierrez
2013
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