Inflammatory Micro-Environmental Cues of Human Atherothrombotic Arteries Confer to Vascular Smooth Muscle Cells the Capacity to Trigger Lymphoid Neogenesis (original) (raw)

A Novel Mechanism Involved in Vascular Inflammation

2013

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Journal of Inflammation This Provisional

2013

PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage

The Role Of Inflammation In Atherosclerosis

2017

To the best people I have ever had in my life, my parents, Elmokhtar Saaoud and Salma Saaoud, for their endless love, support, and encouragements throughout my life pushing me always toward success. To my dear husband, Ismail Ben Issa, I give my deepest expression of love and appreciation for your support, encouragement, and the sacrifice you made during this graduate program. Thank you for your practical and emotional support. To my precious kids, Mohammed, Abdalmuizz, Danah, and Maryam who have been affected in every possible way by this quest. My love for you all can never be quantified. First and for most, I would like to thank my advisor, Dr. Daping Fan, for his admirable guidance, excellent advice, and patience over the past several years. I am very grateful to him for providing me such opportunity to work in his laboratory and great training that is valuable to my future development. I would like to thank all current and past members of Dr. Fan's lab, in particularly Xuemei Jia and Junfeng Wang for their invaluable training and assistance since the first day I joined the group. I would like to thank Yuzhen Wang for her help with the histological analysis.

of Endothelial Cell Inflammatory Responses

2013

Adventitial inflammation and its interaction with intimal atherosclerotic lesions

Frontiers in physiology, 2014

The presence of adventitial inflammation in correlation with atherosclerotic lesions has been recognized for decades. In the last years, several studies have investigated the relevance and impact of adventitial inflammation on atherogenesis. In the abdominal aorta of elderly Apoe(-/-) mice, adventitial inflammatory structures were characterized as organized ectopic lymphoid tissue, and therefore termed adventitial tertiary lymphoid organs (ATLOs). These ATLOs possess similarities in development, structure and function to secondary lymphoid organs. A crosstalk between intimal atherosclerotic lesions and ATLOs has been suggested, and several studies could demonstrate a potential role for medial vascular smooth muscle cells in this process. We here review the development, phenotypic characteristics, and function of ATLOs in atherosclerosis. Furthermore, we discuss the possible role of medial vascular smooth muscle cells and their interaction between plaque and ATLOs.

Molecular and cellular mechanisms of inflammation

Biochemistry (Moscow), 2016

Inflammation is one of the most fundamental and pronounced protective reactions of the organism. From ancient times to the present day, complex and diverse patterns of inflammation development and their role in various diseases have attracted attention of investigators. This issue of Biokhimiya/Biochemistry (Moscow) includes experimental studies and reviews dedicated to various aspects of this important and interesting problem.

Inflammatory Micro-Environmental Cues of Human Atherothrombotic Arteries Confer to Vascular Smooth Muscle Cells the Capacity to Trigger Lymphoid Neogenesis (original) (raw)

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