Chondromyxoid fibroma management: a single institution experience of 22 cases (original) (raw)

Chondromyxoid Fibroma: A Rare Case Report and Review of Literature

Cureus, 2016

Chondromyxoid fibroma (CMF) is one of the rarest benign tumors of cartilaginous origin. It accounts for less than 0.5% of bone tumors and less than two percent of benign bone tumors. It is composed of a mixture of chondroid, myxoid, and fibrous tissues. The diagnosis of CMF depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or chondroid background. We present a case of juxtacortical CMF in a 15-year-old male involving the proximal end of the tibia, which was treated with en bloc excision and bone grafting with excellent results on final follow-up.

Chondromyxoid fibroma of the foot and ankle: 40 years’ Scottish bone tumour registry experience

International Orthopaedics, 2006

Ten cases of histologically proven chondromyxoid fibroma (CMF) of the foot and ankle with a mean follow-up of 6.1 years were retrospectively reviewed using the Scottish Bone Tumour Registry. The patients' mean age was 19 years; there were six males and four females. The anatomical locations were five phalangeal, three metatarsal, one tarsal affecting body of os calcis and one distal tibial. The median delay in presentation was 4.5 months. The modes of presentation were pain only (n=4), painful lump (n=4) and painless lump (n=2). The typical radiological finding was an expansile, lobulated, cystic lesion. Cortical erosion was documented in 80% patients. In four cases, curettage alone was carried out, while five patients underwent curettage along with autogenous bone grafting. One patient with distal phalangeal CMF had a primary toe amputation. Two patients had recurrences 9 and 16 months after their initial curettage. Both of them were males with proximal phalangeal CMF, associated with cortical erosion. Foot and phalangeal CMF initially treated with curettage only should be closely followed up, as we observed a 20% recurrence rate within a 2-year period. Cases featuring cortical erosion require thorough curettage and may require autogenous bone grafting to prevent fracture. Résumé Nous avons revu rétrospectivement à l'aide du registre Ecossais des tumeurs osseuses, dix cas de fibromes chondromyxoides du pied et de la cheville. L'âge moyen était de 19 ans avec une répartition par sexe suivante : 6 garçons et 4 filles. La localisation anatomique de la tumeur était cinq fois une phalange, trois fois un métatarsien, une fois un os du tarse et une fois l'extrémité inférieure du tibia. Le délai moyen de consultation était de quatre mois et demi, les patients consultant quatre fois pour une douleur, quatre fois pour une boiterie douloureuse, deux fois pour une boiterie non douloureuse. Les lésions kystiques étaient radiologiquement typiques de type lobulées. L'atteinte corticale a été retrouvée dans 80% des cas. Pour quatre cas nous avons procédé à un curetage isolé, dans cinq cas à un curetage associé à une auto-greffe. Un cas (atteinte de la phalange distale) a bénéficié d'une amputation d'orteil. Deux cas ont récidivé à neuf et seize mois après le curetage, il s'agissait d'un sujet masculin avec une atteinte de la phalange distale et une érosion corticale. Les fibromes chondromyxoides du pied et de la phalange qui ont initialement été traités par curetage isolé ont récidivé dans les deux ans, dans 20% des cas. Lorsque les lésions entraînent une érosion corticale, il est nécessaire d'associer au curetage une greffe, afin de prévenir le risque de fracture.

Chondromyxoid fibroma of the lateral malleolus: a case report

Journal of orthopaedic surgery (Hong Kong), 2011

Chondromyxoid fibromas account for <1% of primary bone neoplasms. We report one such case occurring in the distal fibula of a 27-year-old woman. The patient underwent curettage, followed by phenolisation, insertion of a Steinmann pin, and cementation. This treatment reduced morbidity, restored stability, and enabled rapid functional recovery. There was no recurrence after 2 years.

Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review

Skeletal Radiology, 2018

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that typically occurs in young adults. Juxtacortical or surfacetype CMF are rarer still and we present the case of a surface-type CMF in a 78-year-old woman, with only one other case described in a patient of a similar age previously. This patient was an otherwise healthy woman who presented for evaluation of a palpable lump in the anterior proximal tibia. Initial radiographs obtained demonstrated a focal soft tissue fullness immediately anterior to the anterior cortex of the proximal tibia, which contained faint chondroid-like matrix internally. There was associated scalloping of the anterior tibial cortex. MRI confirmed the presence of a juxtacortical, enhancing lesion. Subsequent excisional biopsy was performed and histopathology demonstrated features, which was consistent with surface-type CMF. At a 6-month follow-up the patient remained free of recurrence. In a patient of this age, paraosteal chondrosarcoma should be excluded. Surface-type CMF, although rare, has been described in older patients and while it is unlikely to feature in a list of differential considerations on initial imaging, awareness of the entity is important.

Chondromyxoid fibroma of frontal bone: a case report and review of the literature

Turkish neurosurgery, 2008

Chondromyxoid fibroma is an unusual benign tumor of cartilaginous tissues that may be confused with other some malign tumors. It is rarely seen in the skull. A 45-year-old female was admitted with painless bony swelling in the forehead. Computerized tomography demonstrated a well-defined expansive lesion with a sclerotic margin measuring approximately 3 cm in diameter in the right frontal bone. On MRI, T1-weighted images revealed a well circumscribed, lobulated and strongly enhancing lesion. On the T2-weighted images, the lesion showed high heterogeneous signal intensity. The patient underwent tumor excision with craniectomy, then acrylic cranioplasty. The histopathological diagnosis was chondromyxoid fibroma. There was no recurrence in a period of 22-months. In conclusion, chondromyxoid fibroma is a benign primary bone tumor that is located extremely rarely in the frontal bone. Accurate initial diagnosis of such tumors are important for appropriate treatment. En block surgical rese...

Chondromyxoid Fibroma of Calcaneum – A Rare Case Report with Review of Literature

Journal of Evolution of Medical and Dental Sciences, 2021

Chondromyxoid fibroma (CMF) is a slow-growing benign tumour seen in the metaphysis of a long bone. World health organization (WHO) Classification of Bone and Soft Tissue Tumours (2002) defines CMF as ''benign tumour characterized by lobules of spindle or stellate-shaped cells with abundant myxoid or chondroid intercellular material.1 Jaffe and Lichtenstein were the first to describe this tumour in 1943.2 They differentiated CMF as a benign lesion from chondrosarcoma which is a much more common malignant tumour. Chondromyxoid fibroma is a potentially aggressive tumour with a cartilage-like matrix. It accounts for approximately 1 % of all bone tumors.3 CMF is found in older children and young adults. This type of tumour normally affects people between the age of 10 to 30 years.3,4,5 It is associated with high local recurrence and with less than 2 % of malignant transformation5. While the cells of the CMF tumour do not undergo metastasis, but they can invade nearby tissues. It ...

Spinal chondromyxoid fibroma of C2

Journal of clinical …, 2006

Chondromyxoid fibroma of bone (CMF) is a rare benign primary bone neoplasm accounting for less than 0.5% of all primary bone neoplasms. The spine is an uncommon site for this tumour, with forty-two cases reported in the modern English literature. They have clinical ...

Chondromyxoid Fibroma of The Lumbar Spine: Case Report and Review of The Literature

Chondromyxoid fibroma originating from axial skeleton is a very rare benign bone neoplasm. There are a few reported lumbar cases in the literature and it can be pre-operatively misdiagnosed as other tumors of spine. A 20-year-old girl presented to our outpatient clinic with right hip and leg pain of 3 months' duration. Physical and neurological examinations were unremarkable and laboratory test results were within normal limits. Imaging studies revealed a cystic lesion in the right half of the L5 vertebra and extending to the posterior elements of the vertebra. CT-guided biopsy result was inconclusive. Surgery was planned. Digital subtraction angiography and embolization were carried out preoperatively. During surgery, L5 laminectomy and curettage of the lesion were performed, taking care to leave the cortex intact. Bilateral L4, S1, and left L5 transpedicular instrumentation and right L5 vertebroplasty were also carried out. The operation relieved the patient's pain. The pa...