Intraventricular glioblastoma multiforme: Case report (original) (raw)
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A peculiar case of pure intraventricular glioblastoma
Neurological Sciences, 2023
Glioblastoma (formerly named glioblastoma multiforme) is the most common primary central nervous system tumor, representing 45% of all cases and 15% of all intracranial neoplasms [1]. Its typical radiologic findings and localization make it often a lesion easy to diagnose. In MRI it usually appears as an irregularly shaped cystic lesion with ring contrast enhancement in T1-weighted images, localized in subcortical white matter and deep gray matter nuclei of the cerebral hemispheres. It involves more frequently the frontotemporal region followed by parietal lobes [1]. Few articles in literature described cases of intraventricular glioblastomas, defining those as secondary ventricular tumors because of their probable origin primarily from cerebral tissue with consequent transependymal development [2, 3]. Atypical presentations of these tumors make it more difficult to clearly differentiate them from other lesions more commonly located in the ventricular system. We describe a case with a unique radiological presentation: an intraventricular glioblastoma lying entirely within the ventricular walls, involving all the ventricular system, without mass effect or nodular parenchymal lesions.
Intraventricular glioblastoma multiforme mimicking meningioma and review of the literature
Asian Journal of Neurosurgery, 2017
Glioblastoma multiforme (GBM) is the most common primary brain tumor and is usually found in aged persons in the cerebral hemispheres particularly the frontotemporal region. But intraventricular GBM is rare and only few cases have been reported in the literature. We report a case of a 27-year-old man who presented with headache, vision loss in both eyes, and other signs and symptoms of increased intracranial pressure. Computed tomography and magnetic resonance imaging showed an intraventricular, well-circumscribed lesion with homogeneous enhancement of contrast, suggestive of meningioma that is more common than GBM in this location. The patient underwent surgical removal through transcortical route. The final pathologic diagnosis was GBM. We present the clinical features, radiological findings, and surgical management of this case and discuss the pathogenesis and review of the literature of intraventricular GBM.
Pure Intraventricular Glioblastoma
Gulhane Medical Journal, 2017
ÖZET Tümüyle intraventriküler yerleşimli glioblastoma Glioblastoma (GBM) en sık görülen primer malign beyin tümörüdür ve genellikle supratentorial beyin parenkimine yerleşir. Tümüyle intraventriküler yerleşim oldukça nadirdir. 48 yaşında tümüyle intraventriküler yerleşimli GBM'li bir erkek hastayı sunduk. Hastaneye baş ağrısı ve bulantı-kusma ile başvurmuştu ve manyetik rezonans görüntüleme tümüyle lateral ventrikülün sol oksipital hornuna yerleşmiş bir kitle lezyonunu ortaya çıkardı. Tümör sol oksipital kraniotomi ile gros total olarak çıkartıldı. Histolojik inceleme GBM tanısını doğruladı. GBM intraventriküler kitle lezyonlarının ayırıcı tanısında akılda tutulmalıdır. Doğru tanı ve hızlı cerrahi müdahale intraventriküler GBM'si olan hastalarda iyi bir klinik sonuç elde etmek için gereklidir.
Glioblastoma multiforme—report of 267 cases treated at a single institution
Surgical Neurology, 2005
Objective: Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor in adults. We present 267 cases treated at a single institution and discuss clinical characteristics and prognostic factors with regard to the neurosurgical literature. Methods: Included in this study were 267 patients who underwent craniotomy for newly diagnosed GBM between 1990 and 2001 at our department. Clinical charts and radiographic images were reviewed. Association to patient survival was estimated using log-rank test. Results: Median patient age was 61 years (mean, 59.5; range, 22-86 years), the male-female ratio was 1.2:1. In 35 cases (13.1%) the tumor was multicentric. Most of the tumors were classified as primary GBM (87.6%). During follow-up, 72 patients (26.4%) underwent recraniotomy for GBM recurrence and 3 patients (1.1%) developed spinal drop metastases. Overall median survival was 47 weeks (range, 5-305 weeks). The following parameters were significantly associated with prolonged survival: (1) age 61 years or younger, P b .001; (2) Karnofsky performance scale score of 70 or more, P b .001; (3) radiotherapy with a total dose of at least 54 Gy, P b .001; (4) chemotherapy, P b .001; (5) total tumor resection, P = .014; (6) recraniotomy for GBM recurrence, P = .012. Conclusions: Glioblastoma multiforme remains an important cause of morbidity and mortality from intracranial tumors. The overall prognosis is dismal, although interdisciplinary therapy can significantly prolong survival and allows a small subgroup of patients to survive 3 years or more. D
International Journal of Molecular Sciences
While the central nervous system (CNS) tumor classification has increasingly incorporated molecular parameters, there is a paucity of literature reporting molecular alterations found in intraventricular glioblastoma (IVGBM), which are rare. We present a case series of nine IVGBMs, including molecular alterations found in standardized next-generation sequencing (NGS). We queried the clinical charts, operative notes, pathology reports, and radiographic images of nine patients with histologically confirmed IVGBM treated at our institution (1995–2021). Routine NGS was performed on resected tumor tissue of two patients. In this retrospective case series of nine patients (22% female, median (range) age: 64.3 (36–85) years), the most common tumor locations were the atrium of the right lateral ventricle (33%) and the septum pellucidum (33%). Five patients had preoperative hydrocephalus, which was managed with intraoperative external ventricular drains in three patients and ventriculoperiton...
Glioblastoma Multiforme: an Advanced Analysis of 153 Patients and Review of the Literature
Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery, 2017
Objective Glioblastoma multiforme (GBM) is an aggressive primary tumor with frequent recurrences that leaves patients with a short survival time and a low quality of life. The aim of this study was to review the prognostic factors in patients with glioblastoma multiforme. Material and Methods The focus of this retrospective study was a group of 153 patients with supratentorial GBM tumors, who were admitted to a tertiary-care referral academic center from 2005 to 2013. The factors associated with survival and local recurrence were assessed using the hazard ratio (HR) function of Cox proportional hazards regression and neural network analysis. Results Out of the 153 patients, 99 (64.7%) were male. The average age of the patients was 55.69 ± 15.10 years. The median overall survival (OS) and progression-free survival (PFS) rates were 14.0 and 7.10 months respectively. In the multivariate analysis, age (HR = 2.939, p < 0.001), operative method (HR = 7.416, p < 0.001), temozolomide ...
Unusual manifestations of primary Glioblastoma Multiforme: A report of three cases
Surgical Neurology International, 2010
Background: Brain tumors, especially high-grade gliomas, can present with focal or generalized signs due to mass effect, parenchymal infiltration and destruction. In general, at the time of diagnosis, tumors could cause common neurological symptoms and major clinical signs depending on their localization. In rare instances, brain tumors colud be manifested with unusual symptoms. Case Description: We describe three cases presenting with unusual clinical symptoms: ulnar neuropathy, vertigo and syncope attacks. Microscopic total tumor excision was done and histopathological analysis revealed that these tumors were glioblastoma multiforme. Both external beam radiotherapy and chemotherapy were given as adjuvant treatments. Conclusions: Physicians should keep brain tumors in mind in the case of patients who present with atypical symptoms such as those reported here. Brain imaging should be performed over a prolonged period following presentation if the patient's symptoms remain unresolved after adequate treatment.
Intraventricular gliosarcoma: unusual location of an uncommon tumor
Journal of Neuro-Oncology, 2010
Gliosarcomas are uncommon variants of glioblastoma bearing the histological hallmark of two distinct tumor components (high grade glial and sarcomatous). They share similarities with glioblastomas as far as clinicoepidemiological and prognostic factors are concerned. They are commonly cortically-surfacing lesions occurring mostly in the supratentorial compartment. Intraventricular location of a gliosarcoma is very uncommon and reported only once before. We report one such case where the lesion was subependymal and protruded into the ventricle giving the appearance of a truly intraventricluar tumor. We discuss this case and review the relevant literature.