LRRK2 interactions with alpha-synuclein in Parkinson's disease brains and in cell models (original) (raw)
α-synuclein, LRRK2 and their interplay in Parkinson’s disease
Leonardo Aliaga
Future Neurology, 2012
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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
Luigi Bubacco
Molecular Neurodegeneration, 2011
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Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies
George Perry
Neurodegenerative Diseases, 2008
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Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
Juan Troncoso
Neuron, 2009
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G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons
Zhenyu Yue
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016
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Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies
Mark Smith
Neurodegenerative Diseases, 2008
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Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology
Joost le feber
Scientific Reports, 2016
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Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism
Randall Woltjer, Vivek Unni
Cell reports, 2015
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Alteration in α-synuclein mRNA expression in Parkinson's disease
Sarah Eisen
Movement Disorders, 2004
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Parkinson's disease and α-synuclein expression
Kat Gwinn
Movement Disorders, 2011
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The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors
Jayden Lee
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
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LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
Hien Thuy Tran
Molecular Therapy - Nucleic Acids, 2017
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Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α-synuclein, and tau
Jean-Marc Taymans
Bioessays, 2010
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Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
Kristina Zhelcheska
Acta Neuropathologica
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Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease
Suzanne Lesage
Journal of Neuropathology and Experimental Neurology, 2010
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POTENTIAL CONTRIBUTION OF ΑLPHA-SYNUCLEIN DYSREGULATION TO PARKINSON'S DISEASE PATHOLOGY
Ruth Perez
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Potential Contribution of α-Synuclein Dysregulation to Parkinson's Disease Pathology
Ruth Perez
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Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
Andrew Hicks
Cell Death Discovery
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α-Synuclein misfolding and Parkinson's disease
Leonid Breydo, Vladimir Uversky
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
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The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson’s Disease
Ruth Perez, Matthew Benskey, Fredric Manfredsson
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Kinase inhibition of G2019S-LRRK2 restores autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
Anne Picard
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Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain
Laurence Ozmen
Journal of …, 2000
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Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease
Natalia Ninkina
Proceedings of the National Academy of Sciences, 2016
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Modification of α-Synuclein by Phosphorylation: A Pivotal Event in the Cellular Pathogenesis of Parkinson’s Disease
kavina ganapathy
Protein Phosphorylation, 2017
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Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
Nobuo Kohara
Acta Neuropathologica Communications
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Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
Laura Marsh
Proceedings of the National Academy of Sciences, 2005
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High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain
Herman Van Der Putten
PLoS ONE, 2012
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alpha -Synuclein Fibrillogenesis Is Nucleation-dependent. IMPLICATIONS FOR THE PATHOGENESIS OF PARKINSON'S DISEASE
Martin Citron
Journal of Biological Chemistry, 1999
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Alteration in alpha-synuclein mRNA expression in Parkinson's disease
Sarah Eisen
Movement disorders : official journal of the Movement Disorder Society, 2004
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LRRK2 Pharmacological Inhibition Abates α-Synuclein Induced Neurodegeneration
Hisham Abdelmotilib
The Journal of biological chemistry, 2015
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Lrrk2 and α-synuclein are co-regulated in rodent striatum
Pekka Kallunki
Molecular and Cellular Neuroscience, 2008
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Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
Luis Gerardo Aguayo
Frontiers in Neuroscience, 2015
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LRRK2 in Parkinson's disease and dementia with Lewy bodies
Sandra Siedlak, George Perry
Molecular neurodegeneration, 2006
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Clinical Correlations With Lewy Body Pathology in LRRK2 -Related Parkinson Disease
Gianni Pezzoli
JAMA Neurology, 2015
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