Mutation analysis for a patient with Glanzmann thrombasthenia who produced a landmark isoantibody to the α IIb β 3 integrin (original) (raw)
A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg214Trp mutation
Miguel Morales
Journal of Clinical Investigation, 1992
View PDFchevron_right
Two human antibodies reacting with different epitopes on integrin beta3 of platelets and endothelial cells
A. Nurden, Maribel Díaz-Ricart
European Journal of Biochemistry, 1994
View PDFchevron_right
Natural history of platelet antibody formation against αIIbβ3 in a French cohort of Glanzmann thrombasthenia patients
Xavier Pillois
Haemophilia, 2012
View PDFchevron_right
Monoclonal Antibodies to Platelet Glycoprotein IIb/IIIa as Antithrombotic Agentsa
Harvey Berger, Harlan Weisman
Annals of the New York Academy of Sciences, 1991
View PDFchevron_right
A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa
Ellinor Peerschke
Journal of Clinical Investigation, 1983
View PDFchevron_right
Critical Residues of Integrin αIIb Subunit for Binding of αIIbβ3 (Glycoprotein IIb-IIIa) to Fibrinogen and Ligand-mimetic Antibodies (PAC-1, OP-G2, and LJ-CP3)
yoshikazu takada
Journal of Biological Chemistry, 1996
View PDFchevron_right
A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (αIIbβ3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia–like phenotype
Peter Newman
2001
View PDFchevron_right
Truncation of the Cytoplasmic Domain of b 3 in a Variant Form of Glanzmann Thrombasthenia Abrogates Signaling through the Integrin a IIb b 3 Complex
Peter Newman
2013
View PDFchevron_right
Decreased stability and structural heterogeneity of the residual platelet glycoprotein IIb/IIIa complex in a variant of Glanzmann's thrombasthenia
Marie-Christine Kopp
British Journal of Haematology, 1989
View PDFchevron_right
Therapeutic expression of the platelet-specific integrin, IIb 3, in a murine model for Glanzmann thrombasthenia
Richard Hynes
Blood, 2005
View PDFchevron_right
Three novel mutations in the glycoprotein IIb gene in a patient with type II Glanzmann thrombasthenia
János Kappelmayer
Haematologica, 2007
View PDFchevron_right
Variant type Glanzmann thrombasthenia caused by homozygous p.724R>X mutation in β3 integrin
László Muszbek
Thrombosis Research, 2010
View PDFchevron_right
Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex
Peter Newman
Journal of Clinical Investigation, 1997
View PDFchevron_right
Dissociation between fibrinogen and fibrin interaction with platelets in patients with different subtypes of Glanzmann's thrombasthenia: studies in an ex vivo perfusion chamber model
Ludovic Drouet
British Journal of Haematology, 2002
View PDFchevron_right
Antiplatelet antibodies in cases of Glanzmann′s thrombasthenia with and without a history of multiple platelet transfusion
Kanjaksha Ghosh
Indian Journal of Human Genetics, 2009
View PDFchevron_right
Unique Pathway of Thrombin-induced Platelet Aggregation Mediated by Glycoprotein Ib
Gerald Soslau
Carolina Digital Repository (University of North Carolina at Chapel Hill), 2001
View PDFchevron_right
A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia
Peter Newman
Journal of Clinical Investigation, 1991
View PDFchevron_right
Anti–β2-glycoprotein I antibodies in complex with β2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V
Steven Krilis
Arthritis & Rheumatism, 2006
View PDFchevron_right
The glycoprotein Ib complex of human blood platelets
Kenneth Clemetson
European Journal of Biochemistry, 1987
View PDFchevron_right
Detection of the Leu40Arg variant of the platelet glycoprotein IIb/IIIa receptor in subjects with thrombotic diseases
Gyula Mózsik
Thrombosis Research, 2005
View PDFchevron_right
Expression and Purification of a Soluble Functional form of the Platelet alphaIIbbeta3 Integrin
Alain Duperray
European Journal of Biochemistry, 1995
View PDFchevron_right
Further characterization of the thrombasthenia-related idiotype OG. Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3
Diane J Nugent
Journal of Experimental Medicine, 1994
View PDFchevron_right
Use of monoclonal antibodies to study the interaction between an integrin adhesion receptor, GP IIb-IIIa, and its physiological ligand, fibrinogen
John Weisel
ImmunoMethods, 1992
View PDFchevron_right
A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets
David Varon
Proceedings of the National Academy of Sciences, 1983
View PDFchevron_right
Immunodiagnosis of platelet activation in immune thrombocytopenia through scFv antibodies cognate to activated IIb3 integrins
preeti bhoria
mAbs, 2015
View PDFchevron_right
A variant thrombasthenic phenotype associated with compound heterozygosity of integrin β3-subunit: (Met124Val)β3 alters the subunit dimerization rendering a decreased number of constitutive active αIIbβ3 receptors
N. Butta
Thrombosis and Haemostasis, 2004
View PDFchevron_right