Synthesis and Antimicrobial Study of Some Schiff Bases of Sulfonamides (original) (raw)
Objective: The purpose of research was to synthesize the better antimicrobial compounds usingDifferent substituted aromatic aldehydes are chosen as the starting material for the synthesis ofSchiff’s Bases with sulfonamide helps to formation of Schiff bases in presences of alcohol and acidicreagent.Material and methods: Melting points of the synthesized compounds were determined by opencapillary and are uncorrected. The purity of the compounds was checked using precoated TLC plates(MERCK, 60F) using chloroform: methanol (8:2) solvent system. The developed chromatographicplates were visualized under UV at 254nm. IR spectra were recorded using KBr on Shimadzu FTIRmodel 8400 spectrophotometer, 1H NMR spectra in DMSO on a BRUKER FT-NMR instrument usingTMS as internal standard.Results : All the synthesized compounds (Ia-Ij) were purified by successive recrystallization usingethanol. The purity of the synthesized compounds was checked by performing TLC. The structures ofthe synthesized com...
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