Cluster C personality disorder has no independent effect on striatal dopamine transporter densities in major depression (original) (raw)
Related papers
Greater striatal dopamine transporter density may be associated with major depressive episode
Journal of Affective Disorders, 2012
Background: We examined striatal dopamine transporter (DAT) distribution volume ratio (DVR) values in subjects with unipolar or bipolar major depressive episode (versus nondepressed healthy volunteers) using the selective DAT radioligand [ 99m Tc]TRODAT-1 and single photon emission computed tomography (SPECT). We hypothesized that striatal DVR values would be greater in depressed versus non-depressed subjects, and that greater DVR values may represent a possible clinical biomarker of depression. Methods: [ 99m Tc]TRODAT-1 SPECT images were acquired from 39 depressed and 103 nondepressed drug-free subjects. The primary outcome measure was the DVR value of [ 99m Tc] TRODAT-1 binding for the putamen region and the combined putamen plus caudate region. Results: DVR values were significantly correlated across all striatal regions within both subject groups (p b 0.005). Depressed subjects had significantly greater DVR values (versus nondepressed subjects) in the putamen (p b 0.0005) and the combined putamen plus caudate (p b 0.0005) regions. There was no difference in DVR values between unipolar (n = 24) and bipolar (n = 15) depressed subjects, and no difference in DVR values for depressed subjects with or without prior antidepressant exposure. The predictive probability of the putamen or combined putamen plus caudate DVR value to distinguish depressed from non-depressed subjects was significant (p b 0.0005). Limitations: DAT values could potentially be influenced by age, gender, diagnosis, prior psychotropic dug exposure, illness length, or symptom severity. Conclusion: Results confirm prior observations of greater striatal DAT density in depressed versus non-depressed subjects, and suggest that greater DVR values may possibly represent a potential diagnostic biomarker for distinguish depressed from non-depressed individuals.
Striatal dopamine transporter density in major depression
Psychopharmacology, 1999
Rationale: There are no previous data available regarding [ 123 I]β-CIT binding to the dopamine transporter sites in the basal ganglia in depressed patients. Objective : The present study tested the hypothesis that the brain DAT density in depressed patients is lower than that in matched healthy controls. Methods: Fifteen drug-naive outpatients with major depression and 18 healthy controls were investigated using single photon emission computerized tomography (SPECT) with a high-affinity dopamine transporter specific radioligand, 123 I-labeled β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)-tropane). Results: We found a significantly higher [ 123 I]β-CIT uptake in both sides of the basal ganglia in patients with major depression than in the controls (Mann-Whitney U-test, P = 0.002 on the right and P = 0.003 on the left). Conclusions: The radioligand uptake reflecting the DAT density was significantly higher among the patients than in the controls. This finding is unexpected, since it is generally believed that monoaminergic neurotransmission is lower in depression, and therefore it could be assumed that a reduction in dopamine transmission would lead to secondary down-regulation of DAT density. However, it is possible that up-regulation of the DAT may be the primary alteration, which leads to lower intrasynaptic dopamine concentration and to lower dopamine neural transmission.
046 Lang Neuropsychopharmacology 2007
The gene encoding cathechol-O-methyltransferase (COMT) contains a common functional missense polymorphism (Val158Met) that regulates dopamine in an allele-dependent manner. A pivotal role of dopamine neurotransmission in the prefrontal cortex has been implicated in drug-seeking behavior and related personality traits, such as sensation seeking, with some evidence for a gender-specific association. Here, we tested the hypothesis that the COMT Val158Met polymorphism modulates the personality dimension, sensation seeking, in a gender-dependent manner. Study sample included 214 male (age 38.1712.6 years) and 218 female (age 36.1713.6 years) healthy volunteers, who were assessed with Zuckerman's sensation-seeking scale and genotyped for the Val158Met polymorphism (dbSNP:rs4680). Univariate analysis of variance showed that the sensation seeking score was significantly affected by a COMT genotype  gender interaction (F ¼ 5.330, df ¼ 2, p ¼ 0.005). The Val158Met polymorphism was associated with the sensation seeking personality trait in women only. The highest scores in the sensation-seeking scale and in three of the four subscales were observed in female subjects with the Val/Val genotype relative to women carrying the Met allele. Our results suggest that high COMT enzyme activity associated with the Val allele predisposes to high sensation seeking scores in female subjects and add to increasing evidence for a gender specific role of COMT in normal and dysfunctional behavior.
Journal of Affective Disorders, 2019
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PET And SPECT Imaging in Psychiatric Disorders
Objectives: To review recent findings from positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigate the pathophysiology and treatment of schizophrenia, depression, and dementia.
MT-SPECT IN COMPLEX PSYCHIATRIC CASES-2011-TONIJ-5-40
Over the past 20 years brain Single Photon Emission Computed Tomography (SPECT) imaging has developed a substantial, evidence-based foundation and is now recommended by professional societies for numerous indications relevant to psychiatric practice. Unfortunately, SPECT in clinical practice is utilized by only a handful of clinicians. This article presents a rationale for a more widespread use of SPECT in clinical practice for complex cases, and includes seven clinical applications where it may help optimize patient care.
European Neuropsychopharmacology, 2001
Background: There is evidence that Tourette's disorder (TD) is associated with abnormalities in the dopaminergic system involving the 123 dopamine transporter (DAT). Data from [ I]-b-CIT single photon emission computed tomography (SPECT) studies and postmortem findings concerning DAT densities in TD patients are not conclusive. The objective of our study was to measure DAT densities with 123 [ I]-b-CIT binding in TD patients who were either psychotropic drug naive or currently treated with antipsychotics (AP) and healthy controls. Method: Altogether 20 TD patients were investigated. A total of 15 patients were psychotropic drug naive and five were currently treated with AP. Ten psychotropic drug naive patients were compared with ten age and sex matched healthy subjects. Five currently treated patients were compared with five age and sex matched psychotropic drug naive TD patients. The investigation was 123 carried out using [ I]-b-CIT (2-b-carbomethoxy-3-b(4-iodophenyl)-tropane and SPECT. Regions of interest (ROI) were drawn over the striatum and the cerebellum. Results: The DAT densities measured by the striatal / cerebellar (S / C) binding ratio did not differ between drug naive TD patients and the controls. The difference between currently AP treated and psychotropic drug naive TD patients did not reach the level of significance. There was no correlation between the ratio and severity of tics and illness. Conclusion: Our study with psychotropic drug naive TD patients contributed to clarify the inconsistent results concerning the DAT.