Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
Adrian Nika
Immunity, 2010
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Mechanism of Lck Recruitment to the T-Cell Receptor Cluster as Studied by Single-Molecule-Fluorescence Video Imaging
RYOTA IINO
ChemPhysChem, 2003
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Distinct Mechanisms regulate lck spatial Organization in activated T cells
Jérémie Rossy, Ewoud Compeer
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A Weak Lck Tail Bite Is Necessary for Lck Function in T Cell Antigen Receptor Signaling
Lutz Tautz
Journal of Biological Chemistry, 2007
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Modulating Lck Activity Protein Inhibits T Cell Activation by Cutting Edge: T Cell-Specific Adapter
Francesc Marti
2013
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Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy
Valerie Lang
The Journal of Immunology, 2001
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The CD4/CD8:p56 lck complex in T lymphocytes: a potential mechanism to regulate T-cell growth
Elizabeth Barber
Biochemistry and Cell Biology, 1989
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Electron Microscopy Revealed by Calcium Imaging and Cell Response to Antigen Recognition Differential Roles of Lck and Itk in T
Alain Trautmann
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Visualizing Intermolecular Interactions in T Cells
Nicholas Gascoigne
Current Topics in Microbiology and Immunology, 2009
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The T Cell Receptor Triggering Apparatus Is Composed of Monovalent or Monomeric Proteins
Carine Gonçalves da Silva
Journal of Biological Chemistry, 2011
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Molecular interactions at the T cell–antigen-presenting cell interface
Nicholas Gascoigne
Current Opinion in Immunology, 2004
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Quantitative Phosphoproteomic Analysis Reveals a Role for Serine and Threonine Kinases in the Cytoskeletal Reorganization in Early T Cell Receptor Activation in Human Primary T Cells
Irene Wagner-doebler, R. Luna, John Blenis
Molecular & Cellular Proteomics, 2012
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Structural nature of the interaction between T lymphocyte surface molecule CD4 and the intracellular protein tyrosine kinase Ick
Mei-chang Kuo
European Journal of Immunology, 1990
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Intrinsic Signals in the Unique Domain Target p56lck to the Plasma Membrane Independently of CD4
Mark Marsh
The Journal of Cell Biology, 1997
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p56{lck}Independent Activation and Tyrosine Phosphorylation of p72syk by T-Cell Antigen Receptor/CD3 Stimulation
Tomas Mustelin
Proceedings of The National Academy of Sciences, 1994
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Molecular mechanism of T-cell activation: role of protein tyrosine kinases in antigen receptor-mediated signal transduction
Margot Thome
Research in immunology
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The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192
Lise Koll, Vibeke Sundvold-gjerstad
Science signaling, 2014
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Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling
Arthur Weiss
Science Signaling, 2011
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Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation
Arthur Weiss
Immunity, 2002
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Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
Nicholas Gascoigne
Nature Communications, 2014
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The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2
Andrés Alcover, Remi Fagard
European Journal of Immunology, 1989
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Novel Tools to Dissect the Dynamic Regulation of TCR Signaling by the Kinase Csk and the Phosphatase CD45
Arthur Weiss
Cold Spring Harbor Symposia on Quantitative Biology, 2013
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Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor
itoro Akpan
Immunity, 2011
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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
Valarie Barr
The Journal of Cell Biology, 2002
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Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells
Francesc Marti
Journal of Experimental Medicine, 2006
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Biophysical mechanism of T-cell receptor triggering in a reconstituted system
John James
Nature, 2012
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T Cell Receptor Signaling Kinetics Takes the Stage
Yuri Sykulev
Science Signaling, 2010
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Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling
Volkert Siersma
European Journal of Immunology, 2002
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Lck Domains Differentially Contribute to Pre-T Cell Receptor (Tcr)-And TCR- / -Regulated Developmental Transitions
Nancy Longo
Journal of Experimental Medicine, 2000
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Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd
Meseret Habtamu
Scientific Reports, 2018
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Direct observation of ligand recognition by T cells
Michelle Krogsgaard
2002
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