Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia (original) (raw)
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During febrile surveillance in the western Java City of Bandung, Indonesia, a patient with clinical symptoms consistent with hantavirus infection was found to have elevated titers of hantavirus-specific immunoglobulin M (IgM) and IgG antibodies. A subsequent epizoological investigation demonstrated a higher prevalence of hantavirus IgG antibodies in rodents trapped in the vicinity of the patient's home compared with rodents from a control area (13.2% vs. 4.7%, p ¼ 0.036). The Old World Seoul hantavirus was detected by reverse transcriptasepolymerase chain reaction in the organs of 71% of the seropositive rodents tested. This is the first report of a Seoul virus infection in Indonesia supported by clinical, serological, and epizoological evidences. These findings suggest that hantavirus infection should be on the clinical differential diagnosis when acutely ill febrile patients report for care in western Java.
Serological evidence of hantavirus infections in Malaysia
Southeast Asian journal of tropical medicine and public health, 2001
Hantaviruses are primarily rodent-borne and transmission is by inhalation of virus-contaminated aerosols of rodent excreta, especially urine and saliva. The genus Hantavirus, family Bunyaviridae, comprises at least 14 serotypes and the symptoms of clinical illness range from mild fever to severe hemorrhagic manifestations with renal complications. Many countries in Southeast Asia are unaware of the importance of hantavirus infections and give them low priority. Malaysia, like other countries in the region, has conducted very few studies on the epidemiology of hantaviruses - and even these were conducted in the 1980s. Using a more extensive range of hantavirus antigens, we conducted a seroprevalence study of rodents and humans and found further evidence of hantavirus infections. Moreover, the data from the antibody profiles strongly suggest the presence of different hantaviruses at the study sites.
Viruses
Dengue and other common tropical infectious diseases of similar clinical presentation are endemic in Indonesia, which may lead to an underestimation of the prevalence of hantavirus (HTV) infection in the country. To better understand the current burden of HTV infection, this study aimed to both identify acute HTV infection among hospitalized patients with fever and to determine the overall seroprevalence of HTV. These results were further considered within the context of previously reported HTV infection in humans and animals in Indonesia by conducting a review of published literature. As part of an observational cohort study of acute febrile illness, this sub-study retrospectively analyzed blood specimens obtained during admission, during the 2–4-week convalescent period, and three months after admission. Convalescent specimens from patients with clinical signs and symptoms of HTV infection were first screened for HTV IgG. When positive, convalescent specimens and paired acute spec...
Hantavirus infections in humans and commensal rodents in Singapore
Transactions of the Royal Society of Tropical Medicine and Hygiene
To determine the extent of hantavirus infection in Singapore, serological studies using the indirect immunofluorescent antibody (IFA) test were conducted on commensal rodents and on human patients in 4 diagnostic groups. Virus isolation using a Vero E6 cell line was performed on hantaviral antigen-positive rodent lung tissue. Of 142 rodents and 3 insectivores studied, 37 (26%) were seropositive for IFA. Rattus norvegicus was the predominant species captured, with the highest species-specific seropositive rate of 32% (36 of 113). A hantavirus strain, R36, was isolated from one R. norvegicus. Seropositive rates for human patients were: 8% respectively for dengue haemorrhagic fever suspects and for non-A non-B hepatitis patients, 3% for leptospirosis suspects and 2% for acute nephritis patients. 2 patients had marked liver dysfunction but mild renal involvement. This hepatitis-like manifestation appears to be a clinical variant of hantavirus infection.
A newly recognized hantavirus in the Asian house rat (Rattus tanezumi) in Indonesia
Journal of General Virology, 2009
Hantaviral sequences were recovered from the lung tissue of an Asian house rat (Rattus tanezumi) captured in Serang, Indonesia. Phylogenetic analysis of partial L, M and S segment sequences showed that they belonged to a novel hantavirus provisionally named Serang virus (SERV). Notably, SERV is distinct from the hantaviruses associated with rodents of the species Rattus: Seoul virus associated with Rattus norvegicus worldwide and Gou virus isolated from Rattus rattus in China. Instead SERV appeared more closely related to Thailand virus (THAIV) carried by the great bandicoot rat (Bandicota indica). These results suggest the possibility that SERV originated via host-switching, with a possible scenario of (pre)-THAIV 'jumping' from (pre)bandicoots to rats and colonizing this new host species.
Molecular Epidemiological and Serological Studies of Hantavirus Infection in Northern Vietnam
Journal of Veterinary Medical Science, 2009
The distribution of anti-hantavirus antibodies in humans and rodents in northern Vietnam was examined. In total, 837 serum samples from healthy humans (617) and patients with fever (220), living in six different areas were screened for IgG antibodies against Hantaan or Seoul virus (SEOV) by ELISA, IFA, and Western blot analysis. Antibody-positive sera were identified in 7/617 (1.1%) healthy donors, 5/150 port workers in the port of Hai Phong, and 2/185 residents of Ha Nam Province. In comparison, positive sera were detected in 5/220 (2.3%) fever patients in the provinces of Ha Nam (1/58) and Thanh Hoa (4/146). Antibody-positive Rattus norvegicus were found in the provinces of Ha Nam (7/52) and Thanh Hoa (1/67), in Haibatrung District (7/43) in Hanoi, and in Hai Phong Port (21/62), while antibody-positive R. rattus (2/17) were found in Hai Phong Port. Part of the Gc region from the viral genome was amplified by RT-PCR using lung tissue samples from R. norvegicus in Haibatrung (2/7) and Hai Phong Port (7/9), but not from R. rattus (0/2). Viral sequences were located in the SEOV clade and formed a single lineage with Indonesian SEOV, suggesting that Vietnamese SEOV is part of a distinct lineage among Asian SEOVs.
Rodent-Borne Hantaviruses in Cambodia, Lao PDR, and Thailand
EcoHealth, 2011
In order to evaluate the circulation of hantaviruses present in southeast Asia, a large scale survey of small mammal species was carried out at seven main sites in the region (Cambodia, Lao People's Democratic Republic, and Thailand). Small scale opportunistic trapping was also performed at an eighth site (Cambodia).
The Southeast Asian journal of tropical medicine and public health, 2000
A serological survey has been carried out to detect evidence of hantavirus infection in rodents from two provinces of Thailand. This study aimed to examine virus antibody in 354 rodents trapped among 6 different villages of Nakhon Pathom Province (February-March, 1998) and in 326 rodents trapped among 14 villages of Nakhon Ratchasima Province (August-October, 1998). Seroprevalence among rodents from Nakhon Pathom Province (2.3%), was mostly find in Rattus norvegicus (3.8%) and Bandicota indica (2.6%). In Nakhon Ratchasima Province seroprevalence (4.0%) was mostly in Bandicota indica (19.1%) and Rattus exulans (3.5%).
Health Science Journal of Indonesia, 2014
Background: Hantavirus lives and reproduces in the body of rodents. Rattus norvegicuswas one found in the Kepulauan Seribu islands of Indonesia. Hantavirus species Seoul virus (SEOV) is a negative single chain RNA viruses included in the family Bunyaviridae. It has a few specific genes, especially genes S that can be developed for a diagnostic test. The aim of this study was to ascertain the character of gene S of hantavirus species Seoul virus. Methods: Gene sequencing of S Seoul virus from lung tissue of rodents was conducted. DNA fragment sequencing used primer pairs of SEOS-28F and SEOS -360R, VNS-1501F and VNS-CSR. The results of sequencing were analyze by seqscapeprogram to obtain a sequence of nucleotides, and analyzed by Mega5 programs. Phylogenetic analysis was done for homology nucleotides and amino acids which were compared to other hanta virus species from the gene bank. Results: The comparison analysis showed, the highest homology from strain KS74 was 88.4% and the lowe...