Inflammatory and immune pathways in the pathogenesis of periodontal disease (original) (raw)

Inflammation plays a critical role in the pathogenesis of periodontal disease, where the acute response can progress to chronic inflammation if not resolved. This chronic state involves both innate and adaptive immune responses, mediated by microbial interactions in the dental biofilm. Understanding the regulatory pathways of immune and inflammatory responses is essential to elucidate the complex mechanisms underpinning periodontal diseases and potential clinical outcomes stemming from these immunological changes.