The role of elastin peptides in modulating the immune response in aging and age-related diseases (original) (raw)

Aging is closely linked to a phenomenon known as Inflamm-aging, characterized by a persistent low-grade inflammation that skews the immune response towards a pro-inflammatory state. This review explores the role of elastin peptides, products of elastin fiber degradation, in modulating the immune system during aging and in age-related diseases such as atherosclerosis, COPD, and cancer. The findings suggest that elastin peptides can enhance immune responses but may also contribute to chronic inflammation, highlighting their dual role in immunosenescence and the pathogenesis of age-associated diseases.