Testing various hexahydropyridoindoles to act as antioxidants (original) (raw)

Abstract

Five hexahydropyridoindoles, namely stobadine, SM1dM9dM10, SME1i-ProC2, SM1M3EC2, and SMe1EC2, in the form of mono- or dihydrochloride salts, were tested to act as an H atom donor as well as an electron donor. The H atom donating properties of the substances were examined by rotational viscometry - an assay based on hyaluronan free-radical degradation induced by ascorbate plus Cu(II) under aerobic conditions. For evaluating the electron donor properties of the substances, the standard ABTS and DPPH decolorization assays were applied. Results of rotational viscometry showed that in time 1 h and 5 h the most effective preventive antioxidants were stobadine and SME1i-ProC2, respectively. The most effective chain-breaking antioxidant was recorded to be stobadine. The efficacy of the substances analyzed by the ABTS assay increased in the order: SM1M3EC2 > stobadine > SMe1EC2 > SME1i-ProC2 > SM1dM9dM10. Yet, the latter substance demonstrated a prooxidative effect on assaying i...

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