Post-transcriptional regulation of cellular iron homeostasis in metazoans (original) (raw)

Abstract

Iron is an essential yet potentially toxic element for all animal cells. Its absorption, traffic, and use are tightly regulated since no efficient excretion system exists in mammals. This control occurs at two levels, a systemic one dependent on the hormone hepcidin, and a cellular one in which Iron Regulatory Proteins take a major part. These proteins are often considered as mammalian iron sensors, but the actual mechanisms of iron detection remain obscure. They have been investigated here, and in recently published experiments, by combining approaches using recombinant proteins and cellular data obtained in the yeast physiological heterologous context and in human cell lines. The search for accessory proteins modulating the function of these proteins has not returned any positive identification of candidates, but indirect data strongly suggest that these sensors must respond to their cellular environment through molecular interactions. The actual iron species that is/are sensed by...

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