Direct Observation of G-protein Binding to the Human δ-Opioid Receptor Using Plasmon-Waveguide Resonance Spectroscopy
Victor Hruby
Journal of Biological Chemistry, 2003
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Plasmon Resonance Studies of Agonist/Antagonist Binding to theHuman δ-Opioid Receptor: New Structural Insights into Receptor-Ligand Interactions
Victor Hruby is to
Biophysical Journal, 2000
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Structure−Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors
Victor Hruby
Journal of Medicinal Chemistry, 2006
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Different Structural States of the Proteolipid Membrane Are Produced by Ligand Binding to the Human δ-Opioid Receptor as Shown by Plasmon-Waveguide Resonance Spectroscopy
Victor Hruby
Molecular Pharmacology, 2004
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New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors
Richard Agnes
2003
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Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain
Victor Hruby
Life Sciences, 2003
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Plasmon-waveguide resonance spectroscopy: a new tool for investigating signal transduction by G-protein coupled receptors
Victor Hruby
Life Sciences, 2003
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From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes
Philip Portoghese
Journal of Medicinal Chemistry
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Exploring Molecular Mechanisms of Ligand Recognition by Opioid Receptors with Metadynamics
Davide Provasi
Biochemistry, 2009
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Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK2) Receptors by Novel Bivalent Ligands
Eyup Akgun
Journal of medicinal …, 2008
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In Search of Analgesia: Emerging Poles of GPCRs in Pain
Derek Molliver
Molecular Interventions, 2009
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Recent developments in the design of receptor specific opioid peptides
Victor Hruby is to
Medicinal Research Reviews, 1989
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Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry
Seksiri Arttamangkul
eLife, 2019
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Dark Classics in Chemical Neuroscience: Comprehensive Study on the Biochemical Mechanisms and Clinical Implications of Opioid Analgesics
Chemical Methodologies, Ferydoon Khamooshi
Chemical Methodologies
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Controlling the “Opioid Epidemic”: A Novel Chemical Entity (NCE) to Reduce or Supplant Opiate Use for Chronic Pain
Boris Tabakoff
Journal of Psychiatry and Brain Science, 2020
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The Opioid Receptor and Ligands Acting at the Opioid Receptor, as Therapeutics and Potential Therapeutics
Current Pharmaceutical Design
Bentham Science
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A role for heterodimerization of and opiate receptors in enhancing morphine analgesia
Hazel Szeto
Proceedings of the National Academy of Sciences, 2004
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Ligand-Directed Functional Selectivity at the Mu Opioid Receptor Revealed by Label-Free Integrative Pharmacology On-Target
Robert Levenson
PLoS ONE, 2011
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Modulation of Opioid Receptor Ligand Affinity and Efficacy Using Active and Inactive State Receptor Models
Henry I. Mosberg
Chemical Biology & Drug Design, 2012
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New molecules in analgesia
László Urbán
British Journal of Anaesthesia, 1995
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Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain
Victor Hruby is to
Bioorganic & Medicinal Chemistry Letters, 2010
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A Novel G Protein–Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain
Junaid Asghar
Journal of Pharmacology and Experimental Therapeutics, 2019
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Discovery of a Potent and Efficacious Peptide Derivative for δ/μ Opioid Agonist/Neurokinin 1 Antagonist Activity with a 2′,6′-Dimethyl- l -Tyrosine: In vitro, In vivo, and NMR-Based Structural Studies
Tally Largent-Milnes
Journal of Medicinal Chemistry, 2011
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Rodent Models of Persistent Pain in Drug Discovery and Development
William Eckert
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A 500MHz proton nuclear magnetic resonance study of .mu. opioid peptides in a simulated receptor environment
Francesco Lelj, Roberto Tomatis
Journal of Medicinal Chemistry, 1987
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A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain
Junaid Asghar
Journal of Pharmacology and Experimental Therapeutics, 2019
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Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues
Jessica Anand
Biopolymers, 2014
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Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by Fluorescence Cross-Correlation Spectroscopy (FCCS)
Vlad Radoi
2019
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Opioid receptors in analgesic drug design – the past, present and future
Partha Ramasastry
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Gold Nanorods Targeted to Delta Opioid Receptor: Plasmon-Resonant Contrast and Photothermal Agents
Josef Vagner
Molecular Imaging, 2008
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The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics
Current Pharmaceutical Design
Bentham Science Publishers
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Backbone Alignment Modeling of the Structure–Activity Relationships of Opioid Ligands
Victor Hruby
Journal of Chemical Information and Modeling, 2011
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