The Risk Factors of Parenteral Nutrition-associated Cholestasis in Preterm Infants (original) (raw)
2009, Pediatrics & Neonatology
AI-generated Abstract
This research examines the risk factors associated with parenteral nutrition-associated cholestasis (PNAC) in preterm infants, emphasizing the significance of PN duration and energy intake in the first weeks of life. A retrospective study indicated that lower energy intake during the second and third weeks is a critical predictor of PNAC, alongside the established risk of prolonged PN use. While there are promising pilot studies suggesting interventions like ursodeoxycholic acid and erythromycin may mitigate PNAC, more comprehensive research is needed to confirm effective therapeutic and preventive strategies.
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