Astrocyte toxicity in motor neuron disease: progress and future hopes (original) (raw)
Motor neuron disease or amyotrophic lateral sclerosis is a complex multicompartmental disorder that belongs to a spectrum of neurodegenerative conditions ranging from pure motor neuron disease to frontotemporal dementia. The symptoms and causes of death are determined by the progressive and relentless loss of motor neurons in the motor cortex and spinal cord, resulting in paralysis and respiratory failure. However, in the past 10 years, compelling evidence has demonstrated that astrocytes are also affected by the disease mechanisms and actively contribute to the neurodegenerative process. This review focuses on the pathways that are dysregulated in astrocytes and how they affect the relationship between astrocytes and motor neurons in amyotrophic lateral sclerosis. Ongoing research using new methodologies to unravel the contribution of specific cell types to the disease are predicted to open the door to new therapeutic interventions to slow disease progression in amyotrophic lateral sclerosis.
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