Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia (original) (raw)
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Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
Frontiers in Psychiatry, 2021
Social dysfunctions (SD) are frequently observed in subjects with schizophrenia. Some of these dysfunctions are also observed in other neuropsychiatric disorders such as autism spectrum disorders (ASD), major depression, bipolar disorder, or Alzheimer disease. Recently, a characterization of a specific type of SD in schizophrenia has been proposed, with the concept of dis-sociality, which form the core aspect of “Schizophrenic Autism” (SA). The present study aimed to explore the presence in people with schizophrenia of SA, independent of other autistic traits, which can be often found in schizophrenia and other neurodevelopmental disorders. We used a structured interview—the Autism Rating Scale (ARS), an instrument devised to detect and measure SA. Fifty-one outpatients affected by schizophrenia (26 remitted, SCZ-r) and 28 affected by bipolar disorder type 1, with psychotic features, in the euthymic phase (BD-e) were recruited. Before assessing the specificity for schizophrenia of S...
Association Between Autism and Schizophrenia
The Journal of Nervous and Mental Disease, 1994
Although now believed to be two distinct disorders, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) share multiple phenotypic similarities and risk factors, and have been reported to co-occur at elevated rates. In this narrative review, we give a brief overview of the phenomenological, genetic, environmental, and imaging evidence for the overlap between ASD and SSD, highlighting similarities and areas of distinction. We examine eight possible alternate models of explanation for the association and comorbidity between the disorders, and set out a research agenda to test these models. Understanding how and why these disorders co-occur has important implications for diagnosis, treatment, and prognosis, as well as for developing fundamental aetiological models of the disorders.
Frontiers in Psychiatry
Schizophrenia Spectrum Disorders (SSD) and Autism Spectrum Disorders (ASD) are considered separate entities, but the two spectra share important similarities, and the study of these areas of overlap represents a field of growing scientific interest. The PANSS Autism Score (PAUSS) was recently developed specifically to assess autistic symptoms in people living with SSD reliably and quickly. The aims of the present systematic review were to provide a comprehensive assessment of the use of the PAUSS scale in available literature and to systematically analyze cognitive, functional and neurobiological correlates of autistic symptoms measured with this instrument in SSD. The systematic literature search included three electronic databases (PubMed, Scopus and PsycINFO) as well as a manual search in Google Scholar and in reference lists of included papers. Screening and extraction were conducted by at least two independent reviewers. Out of 213 identified records, 22 articles referring to 1...
Background: Individuals with autism and schizophrenia spectrum disorders exhibit similar social, language, and repetitive behavior symptoms. However, there have been few studies comparing specific differences in these domains in individuals with autism spectrum disorder (ASD), versus those at ultra high risk for developing psychotic disorders (UHR) or for those with first episode schizophrenia (FE). This work has implications for understanding the comparative neurobiology of these disorders, for identification of precursors to psychosis and risk prediction, and for intervention. Objectives: The first goal of the study is to distinguish behavioral profiles of ASD, FE, and UHR across domains of reciprocal social interaction, structural and pragmatic language, and sensory/motor symptoms. The second goal is to begin to develop hypotheses about shared genetic and neurobiological mechanisms in ASD, schizophrenia spectrum, and other neurodevelopmental disorders. Finally we seek to consider...
Schizophrenia and Autism Spectrum Disorders
2015
Integrative proteomic analysis of the NMDA NR1 l reveals effects on Conclusions: Taken together, this multi-platform profiling study has identified peripheral changes which are potentially Wesseling et al. Molecular Autism 2014, 5:38
Schizophrenia research, 2017
Schizophrenic (SCZ) and autism (ASD) spectrum disorders share several features including social cognition impairments. In SCZ, the link between symptomatic dimensions and social cognition deficits remains unclear. The Movie for the Assessment of Social Cognition (MASC) test, available in several languages including English, investigates mental state attribution capabilities in complex interpersonal situations. After its translation into French, we used MASC to direct compare social cognition in 36 young participants with SCZ to 19 with ASD and 20 healthy controls (HC) matched for gender, age (18-25y.o.) and level of education. The MASC discriminated each group from the others, patients with SCZ exhibiting difficulties compared to ASD (MASC total score 28.1 (4) and 24.2 (6.6), respectively; p<.001). In the whole sample, MASC scores were inversely correlated with autistic traits, evaluated by autism quotient, and with disorganization symptoms. Finally, in SCZ, over-mentalizing diff...