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Michael P Hay
Australian Journal of Chemistry, 2008
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Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1, 2, 4-benzotriazine 1, 4-dioxides with antitumor activity: the role of extravascular …
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Journal of medicinal …, 2007
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Oxygen Dependence and Extravascular Transport of Hypoxia-Activated Prodrugs: Comparison of the Dinitrobenzamide Mustard PR-104A and Tirapazamine
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International Journal of Radiation Oncology*Biology*Physics, 2007
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Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
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Clinical Cancer Research, 2010
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Hypoxia-selective 3-alkyl 1, 2, 4-benzotriazine 1, 4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity
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Journal of Controlled Release, 2001
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An Analytical Method for Quantifying Transport and Reaction of AntiTumor Drugs in Human Tissues
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Journal of Chemical Engineering of Japan, 2009
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Fundamental & Clinical Pharmacology, 2013
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2010
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Use of Three-Dimensional Tissue Cultures to Model Extravascular Transport and Predict In Vivo Activity of Hypoxia-Targeted Anticancer Drugs
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JNCI Journal of the National Cancer Institute, 2006
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Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model
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In: Multiple Drug Resistance Cell Membranes, Cytosolic pH and Drug Transport in Cancer and MDR: Physics, Biochemistry and Molecular Biology
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Journal of Controlled Release, 2015
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Analysis of Drug Transport Kinetics in Multidrug-resistant Cells: Implications for Drug Action
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Current Medicinal Chemistry, 2001
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Effect of increasing vascular hydraulic conductivity on delivery of macromolecular drugs to tumor cells
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International Journal of Radiation Oncology*Biology*Physics, 1995
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Association of tumor cells chemoresistance mechanisms and suboptimal systemic cytotoxic treatment results
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Libri Oncologici Croatian Journal of Oncology, 2019
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Hypoxia-selective 3-alkyl-1, 2, 4-benzotriazine 1, 4-dioxide bioreductive drugs: Analogues of tirapazamine with improved in vivo activity
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Drug Metabolism and Transport Under Hypoxia
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Current Drug Metabolism, 2013
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Activity of Anticancer Drugs in Relation to the Tumour Microenvironment and Potential to Inhibit Repopulation and Enhance Therapeutic Outcome
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2014
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Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers
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JNCI Journal of the National Cancer Institute, 2006
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Relationship between cytotoxic drug response patterns and activity of drug efflux transporters mediating multidrug resistance
MANUEL RAMÍREZ DE LA TORRE
European Journal of Pharmacology, 1998
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An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours
Stephen Ohms
British Journal of Cancer, 1997
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A Systems Approach for Tumor Pharmacokinetics
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PLoS ONE, 2011
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Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET
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Acta Oncologica, 2010
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Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB 8-5 cells
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 1996
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The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro -to- In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research
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Journal of Pharmaceutical Sciences, 2015
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Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells
Balazs Sarkadi
1999
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Hypoxic cell cytotoxin tirapazamine induces acute changes in tumor energy metabolism and pH:A31p magnetic resonance spectroscopy study
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Radiation Oncology Investigations, 1998
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Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
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Journal of Cancer Research and Clinical Oncology, 2019
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Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines
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Current pharmaceutical biotechnology, 2017
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Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data
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European Journal of Medicinal Chemistry, 2009
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A Mathematical Model of Drug Transport in Human Breast Cancer
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Microvascular Research, 2000
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Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
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Drug delivery, 2015
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The effect of interstitial pressure on therapeutic agent transport: Coupling with the tumor blood and lymphatic vascular systems
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Journal of Theoretical Biology, 2014
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