Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda (original) (raw)
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2020
Background: Uganda has successfully reduced pediatric HIV infections through prevention of mother-to-child transmission of HIV (PMTCT) programs, yet little is known about adherence to infant-specific components of interventions. We hypothesized that infants born to mothers receiving the WiseMama (WM) electronic drug monitoring (EDM)-based adherence intervention would have increased uptake of six-week post-natal nevirapine (NVP) infant prophylaxis and better adherence to six-week early infant diagnosis (EID) HIV testing. Methods: At two sites in Uganda, the Wise Infant Study (WIN) prospectively followed an infant cohort. Infants were born to women enrolled in an RCT testing the effect of real-time reminders delivered via EDM on maternal adherence to antiretroviral therapy. We assessed intrapartum and discharge receipt of NVP prophylaxis using pharmacy and infant HIV DNA testing laboratory data. Results: Of 121 women eligible for WIN, 97 (80%) consented and enrolled; 46 had been rando...
Missed opportunities : prevention of mother-to-child transmission of HIV in Uganda
2012
Background: Despite the existence of effective interventions such as prophylactic antiretroviral medicines, mother-to-child transmission (MTCT) of HIV is still a major reason for HIV transmission in sub-Saharan Africa. Antenatal care (ANC) facilities are the main location for implementing prevention of MTCT (PMTCT) programmes and HIV testing is the first step in PMTCT.
BMC Infectious Diseases, 2020
Background Loss to follow-up (LTFU) deprives HIV-exposed infants the lifesaving care required and results in exposing HIV free infants to virus requisition risk. We aimed to determine the rate of LTFU, postnatal mother-to-child HIV-transmission (MTCT) and to identify maternal factors associated with LTFU among HIV-exposed infants enrolled at Mbarara Regional Referral Hospital PMTCT clinic. Methods Study participants were infants born to HIV-positive mothers enrolled in the PMTCT clinic for HIV care at Mbarara Regional Referral Hospital. While access database in the Early Infant Diagnosis (EID) clinic provided data on infants, the open medical record system database at the ISS clinic provided that for mothers. Infants were classified as LTFU if they had not completed their follow-up schedule by 18 months of age. At 18 months, an infant is expected to receive a rapid diagnostic test before being discharged from the PMTCT clinic. Postnatal MTCT of HIV was calculated as a proportion of ...
African Health Sciences
Background: Over 90% of new paediatric HIV infections are acquired through mother to child transmission. Prevention of mother to child HIV transmission (PMTCT) research in sub-Saharan Africa informed WHO guidelines which enabled implementation of PMTCT programs globally. Objectives: To describe Makerere University-Johns Hopkins University (MU-JHU) perinatal HIV prevention research and implementation of the Mulago National Referral Hospital (MNRH) PMTCT program. Methods: Perinatal HIV prevention studies conducted at MU-JHU between 1997–2016 were summarized. Program aggregated data was extracted and analyzed using STATA 15. Results: In 1999, the HIVNET 012 study demonstrated that single-dose nevirapine (sdNVP) to the mother at onset of labor and to her newborn, reduced MTCT by nearly 50%. In 2016, the PROMISE study documented the safety and efficacy of ART during pregnancy and breastfeeding period. Program implementation at MNRH started in 2000. Uptake of HIV testing increased from 70...
Strategies to Combat Mother-to-Child Transmission of HIV in Uganda: A Review
Elite Journal of Public Health, 2024
Mother-to-Child Transmission (MTCT) of HIV remains a significant public health concern in Uganda, demanding effective strategies to prevent and mitigate its impact. This comprehensive review critically examines the various approaches and interventions implemented to combat MTCT in the Ugandan context. Key themes include Prevention of Mother-to-Child Transmission (PMTCT) programs, the role of Antiretroviral Therapy (ART) for pregnant women, the strength of healthcare infrastructure, community engagement and education, and the influence of policy interventions. The review synthesizes current evidence, explores challenges faced, and proposes future directions for more targeted and sustainable efforts in combating MTCT of HIV in Uganda. This analysis contributes to the global discourse on HIV prevention and underscores the importance of multifaceted strategies in achieving meaningful progress in the fight against MTCT.