Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda (original) (raw)

This study investigates three drug combinations for treating late-stage Trypanosoma brucei gambiense sleeping sickness, focusing on their efficacy and safety in a randomized clinical trial conducted in Uganda. Results show varying cure rates, with the combination of N (likely referring to a specific drug) and E demonstrating the highest efficacy and lowest adverse events. The study highlights the need for safer treatment alternatives as melarsoprol has significant toxicity and treatment failures.