Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ɛ, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae (original) (raw)

2012, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Please cite this article in press as: J. Kraszewska, et al., Defect of Dpb2p, a noncatalytic subunit of DNA polymerase , promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae, Mutat. Res.: Fundam. Mol. Mech. Mutagen. (2012), http://dx.Available online xxx Keywords: DNA polymerase epsilon (Pol ) DNA polymerase zeta (Pol ) Error-prone DNA polymerase Spontaneous mutagenesis DNA replication fidelity a b s t r a c t The Saccharomyces cerevisiae DNA polymerase epsilon holoenzyme (Pol HE) is composed of four subunits: Pol2p, Dpb2p, Dpb3p and Dpb4p. The biological functions of Pol2p, the catalytic subunit of Pol , are subject of active investigation, while the role of the other three, noncatalytic subunits, is not well defined.