Imaging of hibernomas: A retrospective study on twelve cases (original) (raw)
Related papers
CT and MR characteristics of hibernoma: six cases
Clinical Imaging, 2008
Purpose: The purpose of this study was to describe the computed tomography (CT) and magnetic resonance (MR) imaging findings of hibernoma. Materials and methods: We retrospectively evaluated imaging findings of CT and MR examinations of six patients (three men and three woman, aged 27-48 years) with histopathological diagnosis of hibernoma. Results: On CT examination, the lesions were slightly hyperdense, and on T1and T2-weighted MR images, they were isointense or slightly hypointense compared to the subcutaneous fat. All of these lesions showed contrast enhancement and one out of the six lesions had internal linear septations. Conclusion: Hibernoma has a wide spectrum of CT and MR imaging findings, which should be considered in differential diagnosis, especially with other lipomatous lesions.
Hibernoma - two patients with a rare lipoid soft-tissue tumour
BMC medical imaging, 2015
Hibernomas are rare benign soft-tissue tumours arising from brown fat tissue. Although imaging characteristics are not specific certain imaging features, common locations and patient demographics may suggest hibernoma as a differential diagnosis. We report on two 48-year-old male patients with hibernoma. The tumour presented with local swelling of the inguinal region in the first patient and was an incidental imaging finding in the second patient. Imaging included magnetic resonance imaging in both patients and computed tomography as well as (18) F-fluorodeoxyglucose positron emission tomography-computed tomography in the second patient. In both cases histological diagnosis was initially based on excisional and needle core biopsy, respectively. Complete surgical resection confirmed the diagnosis of hibernoma thereafter. In soft tissue tumours with fatty components hibernoma may be included into the differential diagnosis. Because of the risk of sampling errors in hibernoma-like tiss...
International journal of clinical and experimental pathology, 2013
Hibernoma is a rare benign fat-forming soft tissue tumor that differentiates similar to brown fat, hence an origin from remnants of fetal brown adipose tissue has been proposed. Mainly young adults are affected, usually without significant clinical symptoms. We report on four patients with hibernomas, who were treated at our hospital during the last 10 years. The clinicopathologic and immunohistochemical features are presented and treatment and follow-up data discussed. Patients were 2 women and 2 men aged 21-67 years (mean: 45 yrs) who presented with a slowly growing, painless mass. The anatomic location was the thigh, upper arm, lateral thoracic wall and paravertebral soft tissue. Two of them were diagnosed preoperatively through a percutaneous core needle biopsy and the other two underwent surgery because of high clinical and radiological suspicion of liposarcoma. The tumor's size ranged from 7 cm to 15.5 cm (mean: 11 cm). All were deep-seated subfascial intramuscular masses....
A case of a rare hibernoma tumour and a brief literature review
A case of a rare hibernoma tumour and a brief literature review, 2023
Hibernomas refer to benign tumours of immature adipose tissue known a brown fat. They are most commonly found in areas where brown adipose tissue is still present in adulthood such as the shoulder, back, neck, best, arm and abdomen. This case study describes a 60 year old male who presented with a growing 15 mm lump in the right forearm. On examination, tenderness in the area surrounding the mass was elicited. A magnetic resonance image of the right forearm was performed which reported a large intramuscular lipomatous tumour within the brachioradialis muscle, in close relation to the neuromuscular bundle. Surgical excision was performed successfully. Histology was consistent with a diagnosis of a hibernoma tumour. The patient healed well with no evidence of infection or recurrence on follow up.
Hibernoma of the thigh: a lipoma-like variant rare tumour mimicking soft tissue sarcoma
BMJ case reports, 2012
A 43-year-old Caucasian woman appeared with painless progressively enlarging tumour of the anterior part of the left thigh of approximately 6 months' duration. A differential imaging diagnosis of liposarcoma or large lipoma was made. An excisional biopsy was performed with complete removal of a large lobulated and encapsulated grossly ovoid mass. Frozen section diagnosis was unidentified lipomatous tumour with no evidence of malignancy. The final pathological diagnosis was lipoma-like hibernoma. The patient's postoperative course was uneventful and discharged on the seventh postoperative day with full function of the involved leg. Hibernoma is benign tumour and it is not known to recur after complete local excision which is the treatment of choice.
A Diagnostic Dilemma of a Subcutaneous Hibernoma: Case Report
American Journal of Case Reports, 2020
Rare disease Background: Subcutaneous lipomatous lesions are commonly encountered in clinical practice. Hibernoma is a rare subtype of the benign lipomatous tumor, representing 1% of all types. It poses a challenge due to the difficulty of differentiating it from atypical lipomatous lesions and liposarcomas, which may lead to possible inappropriate diagnosis and management. Case Report: We report a case of a 33-year-old male who presented with a right upper thigh swelling noticed some time prior to presentation that had started increasing in size prior to his presentation. The magnetic resonance imaging (MRI) was unable to rule out atypical lipomatous tumor and liposarcoma. An ultrasound-guided biopsy gave a diagnosis of hibernoma. The patient underwent a wide local excision, which confirmed the diagnosis of hibernoma. At the 3-year follow-up, there was no evidence of local recurrence. Conclusions: Hibernoma has been reported in the literature to be discovered incidentally by radiological imaging done for other causes. However, hibernomas raise a diagnostic challenge because in most imaging modalities they are indistinguishable from other malignant tumors. A wide local excision with negative margins is key to resolving the diagnostic dilemma that a hibernoma presents, as it will provide a definitive diagnosis differentiating it from other lipomatous lesions and prevent any future recurrence. Caution is advised when dealing with lipomatous lesions, as they often overlap with malignancy. Furthermore, an MRI should be done for any subcutaneous lesion that is larger than 5 cm or shows recent growth. A biopsy can resolve the diagnostic dilemma with caution to the hypervascularity of such tumors.
Hibernoma: unusual localization of a rare tumor
2021
Adipose tumors are dominated by lipomas, but other rarer entities may be encountered such as hibernoma which is a benign tumor that develops from brown fat. The thigh is the preferred location for hibernomas, but the tumor can appear in other areas. The upper limb is a rare localization and there is only one case of hibernoma on the hand already reported in the English literature. We report the case of a hibernoma of the palmar aspect of the hand. The tumor had no clinical specificities. MRI showed an uncertain appearance mimicking liposarcoma. The diagnosis was only confirmed by histological study. The treatment consisted of complete excision of the tumor. At a follow-up of 8 months, there was no recurrence.
Deep-seated Hibernoma of Thigh: A Rare Benign Adipocytic Tumor
Journal of the College of Physicians and Surgeons Pakistan, 2019
Hibernoma is a rare benign soft tissue adipocytic tumor. Mostly found in adults, it is usually located in the limbs, and is deepseated or intramuscular. Usually asymptomatic, it causes symptoms when it becomes large enough to compress adjacent structures, mimicking well differentiated liposarcoma clinically and radiologically. We present a case report of a deepseated hibernoma of thigh. Radiological investigation and incisional biopsy were done to diagnose and define the surgical roadmap to completely excise it. We describe our technique to precisely control feeding vessels and meticulous dissection to preserve thigh muscles to retain function.
Hibernoma of the axillary region: a rare benign adipocytic tumor
Rare Tumors, 2010
Hibernoma is a rare benign tumor considered to arise from remnants of fetal brown adipose tissue. It tends to occur in sites where brown fat persists beyond fetal life, such as the interscapular region, but can occur in sites where brown fat is usually absent in adults. Clinically, hibernomas are slow-growing, asymptomatic tumors. However, unlike lipomas, MRI findings sometimes mislead clinicians to diagnose a malignant neoplasm. We describe a 63-year-old male with an axillary hibernoma involving the brachial neurovascular bundles and mimicking a well-differentiated liposarcoma, from which it should be distinguished.
Iranian Journal of Pathology, 2017
Hibernoma Benign Lipomatous Tumor Brown Fat Intramuscular Hibernoma Scapular Hibernomas are extremely rare benign tumors of adipose tissue characterized by an admixture of brown fat cells with granular, multivacuolated cytoplasm and white fat cells. Hibernomas account for 1.6% of benign adipose tissue tumors and approximately 1.1% of all adipocytic tumors. Around 10% of these cases are intramuscular. It was initially described in the early 1900s as being composed of brown fat. Hibernomas usually occur in third to fourth decades of life and the most frequent sites being thigh, trunk, shoulder, back etc. Cytological differential diagnoses of hibernoma include well differentiated liposarcoma, myxoid/round cell liposarcoma, chondroid lipoma and benign granular cell tumor. Due to its abundant vascularity evident on angiography, it can sometimes mimic a malignant lesion, from which it needs to be distinguished as complete surgical excision is the only treatment required for a hibernoma. Moreover, it has no malignant or metastatic potential. We presented a rare case of intramuscular hibernoma of the scapular region in a 34-year-old male, in which cytology was reported as pleomorphic fibrolipomatous malignant lesion.