Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles (original) (raw)

The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10 -24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18 -fold more potent than BHT (IC 50 2.3 £ 10 24 M) with 1.3 £ 10 25 M and 1.2 £ 10 25 M IC 50 values, respectively, by interaction of the stable DPPH free radical.