2015(35B-28) (original) (raw)

The aim of the present study is to compare between the anti-inflammatory effect of simvastatin, rosuvastatin alone and in combination with prednisolone on Acetic acid (10%concentration) induced inflammatory bowel disease model in rats. Material and method, Ninety six adult females albino rats weighting 160-210g were used. Induction of colitis was done in 6 th day of experiment. In prophylactic groups drugs were administrated 5 days before and 7days after induction of colitis. In therapeutic groups drugs were administrated7days after induction of colitis. the lesion in distal colone scored macroscopically and microscopically.Disease activity index (DAI), colon weight and colonic myeloperoxidase (MPO),and tumor necrosis factor alpha (TNFα) levels were assissed. Results,The present study showed that intra-colonic administration of 1 ml of acetic acid (10% conc.) using polyethylene tube (8F) resulted in significant increase in mean DAI, mean colon weight, mean colonic MPO,and TNFα levels. Also there was significant increase in mean macroscopic and microscopic pathological score of colon. Prophylactic and therapeutic administration of either simvastatin or rosuvastatin showed significantly decrease in inflammatory parameter. however, rosuvastatin and prednisolonewere more significant than simvastatin. moreover there was no significant difference between rosuvastatin and prednisolone.Conclusion,both simvastatin and rosuvastatin are significantly improving inflammatory parameters in prophylactic and therapeutic groups on IBD model, but effect of rosuvastatin is more significant than that of simvastatin. Moreover, rosuvastatin almost has same effects as prednisolone.