2D Bipyrimidine silver(I) nitrate: Synthesis, X-ray structure, solution chemistry and anti-microbial activity (original) (raw)
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Dalton Transactions, 2006
The synthesis and low temperature crystal structures of [Ag(quinoxaline)] n (NO 3 ) n , 1, [Ag(2,5-dimethylpyrazine)(NO 3 )] n , 2 and [Ag 4 (3-aminopyridine) 4 (NO 3 ) 4 ] n 3 are presented. The quinoxaline compound forms a 1D coordination polymer with the characteristic linear 2-coordination figure of silver(I), the N-Ag-N angle being 164.2(1) • , and only weak silver-nitrate interactions. In addition there is an interaction giving pairs of parallel chains as the main structural theme. The 2,5-dimethylpyrazine compound has approximately trigonal-planar coordination, also binding one nitrate at the relatively short Ag-O distances 2.444(3) Å and 2.484(3) Å , respectively, for the two crystallographically different silver atoms. This also results in a 1D coordination polymer that, despite the large differences in the Ag(I) coordination environment, is isostructural with 1.
Silver(I) complexes of 2,2 0-bipyridine (bpy) and 1,10-phenanthroline (phen), namely [Ag(bpy) 2 ]NO 3 , [Ag (bpy)(CN)]Ábpy, [Ag(phen) 2 ]NO 3 , [Ag(phen)(CN)] and [Ag(phen)(CN)]Áphen, were prepared and characterized by elemental analysis and IR, 1 H and 13 C NMR spectroscopies. In the nitrate complexes, both the bpy or phen ligands were bound to the Ag(I) ion, whereas in the cyanide complexes only one N,N 0-chelating ligand was found in the inner coordination sphere. For a reliable interpretation of the experimental IR and NMR spectra of the complexes studied, molecular modelling and the corresponding spectral calculations were performed using density functional theory (DFT). The spectroscopic data were consistent with the presence of N,N 0-bidentate linked bpy and phen ligands in the complexes and indicated coordination of the cyanido group to the Ag(I) ion. The antimicrobial activities for two of the complexes were evaluated by minimum inhibitory concentration experiments and the results showed that the complexes (especially [Ag(phen) 2 ]NO 3) exhibited significant activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and molds (Aspergillus niger, Penicillium citrinum), while their activity against yeasts (Candida albicans, Saccharomyces cerevisiae) was poor.
Inorganic Chemistry, 2010
Ag(2-amino-3-methylpyridine) 2 ]NO 3 (1) and [Ag(pyridine-2-carboxaldoxime)NO 3 ] (2) were prepared from corresponding ligands and AgNO 3 in water/ethanol solutions, and the products were characterized by IR, elemental analysis, NMR, and TGA. The X-ray crystal structures of the two compounds show that the geometry around the silver(I) ion is bent for complex 1 with nitrate as an anion and trigonal planar for complex 2 with nitrate coordinated. ESI-MS results of solutions of 2 indicate the independent existence in solution of the [Ag(pyridine-2-carboxaldoxime)] þ ion. The geometries of the complexes are well described by DFT calculations using the ZORA relativistic approach. The compounds were tested against 14 different clinically isolated and four ATCC standard bacteria and yeasts and also compared with 17 commonly used antibiotics. Both 1 and 2 exhibited considerable activity against S. lutea, M. lutea, and S. aureus and against the yeast Candida albicans, while 2-amino-3-methylpyridine is slightly active and pyridine-2carboxaldoxime shows no antimicrobial activity. In addition, the interaction of these metal complexes with DNA was investigated. Both 1 and 2 bind to DNA and reduce its electrophoretic mobility with different patterns of migration, while the ligands themselves induce no change.
Inorganic …, 2010
Ag(2-amino-3-methylpyridine) 2 ]NO 3 (1) and [Ag(pyridine-2-carboxaldoxime)NO 3 ] (2) were prepared from corresponding ligands and AgNO 3 in water/ethanol solutions, and the products were characterized by IR, elemental analysis, NMR, and TGA. The X-ray crystal structures of the two compounds show that the geometry around the silver(I) ion is bent for complex 1 with nitrate as an anion and trigonal planar for complex 2 with nitrate coordinated. ESI-MS results of solutions of 2 indicate the independent existence in solution of the [Ag(pyridine-2-carboxaldoxime)] þ ion. The geometries of the complexes are well described by DFT calculations using the ZORA relativistic approach. The compounds were tested against 14 different clinically isolated and four ATCC standard bacteria and yeasts and also compared with 17 commonly used antibiotics. Both 1 and 2 exhibited considerable activity against S. lutea, M. lutea, and S. aureus and against the yeast Candida albicans, while 2-amino-3-methylpyridine is slightly active and pyridine-2carboxaldoxime shows no antimicrobial activity. In addition, the interaction of these metal complexes with DNA was investigated. Both 1 and 2 bind to DNA and reduce its electrophoretic mobility with different patterns of migration, while the ligands themselves induce no change.
Applied Sciences, 2020
Three broad spectrum Ag(I) complexes against MDR (multi drug resistance) and ATCC standard bacteria as well as the fungus C. albicans were presented. The three well-known structurally-related Ag(I) complexes, [Ag(pyridine-3-carboxaldhyde)2NO3], 1, [Ag3(2-pyridone)3(NO3)3]n, 2, and [Ag(3-hydroxypyridine)2]NO3, 3, were prepared by the direct combination of AgNO3 with the corresponding pyridine ligands in a water-ethanol mixture. 1 and 3 are molecular compounds while, 2 is a 2D coordination polymer with sheets bridged by strong homoleptic R2,2(8) hydrogen bonds between ligands giving the ins topology. Different contacts affecting the molecular packing in their crystal structures were computed by employing Hirshfeld analysis. Charge transferences from the ligand groups to Ag(I) were analyzed using natural population analysis. The effect of protonation and metal coordination on the tautomerism of 2-pyridone was analyzed using data from the Cambridge Structure Database (CSD). It was found...
Inorganica Chimica Acta, 2008
The reaction of [Ag 4 (hfac) 4 (THF) 2 ] (hfac À = 1,1,1,5,5,5-hexafluoroacetylacetonate, THF = tetrahydrofurrane) with 2,2 0-bipyrimidine (bpm) leads to single crystals. They crystallise in the triclinic system, space group P 1. Their structure consists of [Ag 4 (hfac) 4 (l 2-bpm) 3 ] tetranuclear complexes. In this complex, Ag(I) ions adopt distorted square planar and trigonal prismatic geometries. When [Ag 4 (hfac) 4 (THF) 2 ] is replaced by monohydrated silver(I) perchlorate, a one-dimensional (1D) compound with a formula of [[Ag(l 2-bpm)] + ] n , nClO 4 À is obtained as single crystals. They crystallise in the monoclinic system, space group P2 1 /c. Their structure consists of [[Ag(l 2bpm)] + ] n chains separated by non-coordinated perchlorate ions. In the chains, the Ag(I) centres adopt a square planar geometry. Finally, starting from [[Ag(l 2-bpm)] + ] n , nClO 4 À and sodium oxalate ðNa 2 ox; ox ¼ C 2 O 2À 4 Þ, another 1D compound with a formula of [Ag(l 2bpm)(l 2-ox)] n , 4nH 2 O is obtained as single crystals. They crystallise in the triclinic system, space group P 1. In these chains, bipyrimidine and oxalate are alternate. They generate a square planar geometry around the Ag(I) cations.
Journal of Chemical Sciences, 2015
Two Ag(I) complexes, [Ag(HL) 2 ]ClO 4 (1) and [Ag(HL) 2 ]NO 3 •H 2 O(2), where HL is pyridine 2carboxamide, have been synthesized and characterized by various spectroscopic techniques. The X-ray crystal structural analyses indicate that both the complexes consist of slightly distorted square planar silver(I) ions and ligand-supported weak Ag••••Ag metallophilic interactions. Both the complexes show photoluminescence in solid state and acetonitrile solution at room temperature. Antimicrobial studies have been performed with these silver(I) complexes against various gram +ve, gram −ve bacterial and fungal species.
New Journal of Chemistry, 2014
The synthesis, crystal structures, DFT and antimicrobial studies of three novel complexes of silver: [Ag(THEEN)] 2 (PIC) 2 (1), [Ag(THPEN)] 2 (PIC) 2 (2) and [Ag(TEAH 3 ) 2 ](PIC) (3), have been reported in the present work, where THEEN/THPEN (N,N,N 0 ,N 00 -tetrakis(2-hydroxyethyl/propyl)ethylenediamine) are tetrapodal ligands and TEAH 3 (tris(2-hydroxyethyl)amine) is a tripodal ligand. Complexes (1) and (2) are dinuclear, whereas (3) is mononuclear. Complex (1) adopted a see-saw geometry with coordination number four, whereas (2) and (3) are five coordinated. Complex (2) acquired distorted square-pyramidal geometry, whereas complex (3) acquired distorted trigonal-bipyramidal geometry. Extensive hydrogen bonding interactions have been found in all three complexes. The primary coordination sphere of the newly synthesized silver(I) complexes has been optimized, structural parameters have been calculated and the energy gaps of the frontier orbitals have been predicted with the B3LYP/6-31G/LANL2DZ level of theory. Structural parameters from the crystallographic and DFT studies are in good agreement with each other. The relatively smaller calculated HOMO-LUMO energy gaps (HLG) suggest charge transfer transitions. Antimicrobial studies have been performed with the new silver(I) complexes against gram +ve bacteria (Staphylococcus aureus), gram Àve bacteria (Serratia marcescens, Sphingobium japonicum and Stenotrophomonas maltophilia) and fungal species (Candida albicans, Aspergillus niger and Saccharomyces cerevisiae). Dinuclear complexes and exhibited remarkable results. All the synthesized silver(I) complexes have been proven to be better antibacterial and antifungal agents, even than their standard drugs (ciprofloxacin and fluconazole) and can be used as effective antimicrobial agents and potential drugs in the future.