Clinical predictors of depression in patients with low-grade brain tumors: consideration of a neurologic versus a psychogenic model (original) (raw)
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Predicting major depression in brain tumor patients
Psycho-Oncology, 2002
Very few studies have been performed utilizing DSM criteria to diagnose major depressive disorder (MDD) in adult brain tumor patients. This study aimed to diagnose MDD in this population using DSM-IV criteria. Eighty-nine adult brain tumor patients were examined in an ambulatory neuro-oncology clinic setting using a structured psychiatric interview which followed current DSM-IV diagnostic criteria for MDD. This sample was interviewed and evaluated on a one-time basis. The patients were referred for evaluation on a consecutive basis. Multiple regression was used to model critical independent variables to predict MDD. Twenty-eight percent of the sample (N ¼ 89) were found to have major depressive disorder using DSM-IV criteria. Key predictors of MDD included frontal region of tumor location (p ¼ 0:001), combined sadness and lack of motivation symptoms (p ¼ 0:0001), and family psychiatric history (p ¼ 0:006). The multiple regression models account for 37% of variance in predicting MDD (R 2 ¼ 0:37). A substantially higher incidence of MDD was found in this sample of adult brain tumor patients compared with other adult, ambulatory cancer patients previously evaluated with DSM criteria. The incidence of MDD was about triple that found in other published studies using DSM criteria.
Journal of Clinical Oncology, 2015
All cancer patients experience distress from the diagnosis, the effects of the disease or the treatment. Clinically significant distress decreases overall quality of life and the recognition of distress with prompt intervention is essential. The National Comprehensive Cancer Network distress thermometer (NCCN-DT) is a validated measuring tool that has been utilized in the primary brain tumor population to detect psychologic distress thereby provoking a referral process to the appropriate support system. Brain tumor patients commonly reported emotional and physical distress encompassing: fatigue, fears, memory and concentration and worry. More research is needed to identify the stressors of all primary brain tumor patients and their caretakers and integrate appropriate interventions to improve health-related quality of life in both groups.
Neuro-oncology practice, 2015
Background. The impact of primary malignant brain tumors on patient quality of life and psychological functioning is poorly understood, limiting the development of an evidence base for supportive interventions. We conducted a thorough systematic review and quality appraisal of the relevant literature to identify correlates of health-related quality of life (HRQoL) and psychological functioning (depression, anxiety and distress) in adults with primary malignant brain tumors. Method. Twenty-three articles met predefined inclusion criteria from a pool of peer-reviewed literature published between January 1984 and July 2015 (N ¼ 2407). Methodological quality of included studies was assessed using an adapted version of the Newcastle-Ottawa Scale. Results. The overall methodological quality of the literature was moderate. Factors relating consistently with HRQoL and/or psychological functioning were cognitive impairment, corticosteroid use, current or previous mental health difficulties, fatigue, functional impairment, performance status and motor impairment. Conclusions. Practitioners should remain alert to the presence of these factors as they may indicate patients at greater risk of poor HRQoL and psychological functioning. Attention should be directed towards improving patients' psychological functioning and maximizing functional independence to promote HRQoL. We outline several areas of future research with emphasis on improved methodological rigor.
Impact of Anxiety and Depression on Quality of Life in Elderly Patients with Brain Tumor
International Journal of Indian Psychology, 2023
Background: Psychological health plays a crucial role in the well-being and quality of life. Diagnosis of brain tumor and subsequent surgery can have a significant impact on a patient's well-being especially with the natural course of ageing. The uncertainty of the diagnosis, the potential impact on daily functioning, after effects of the surgery can all contribute to psychological distress, including anxiety and depression in an elderly person. The aim of the present study is to find the influence of depression and anxiety on the quality of life of elderly people who underwent brain tumor resection. Method: Using descriptive research design a sample of 50 post operative patients between age group 55-75 were selected. The Malayalam version of HADS and WHOQOL-BREF were administered along with exploring other sociodemographic variables. Results: Correlational analysis, ANOVA and post hoc tests were employed. The results showed that high anxiety levels were associated with a lower QoL (p = .006). However, depression levels did not have a significant impact on QoL. Additionally, there was a positive correlation between general health and QoL score (r = 0.685, p < .001), indicating that better general health was associated with a better QoL. Conclusion: Study suggest that psychological and physical factors should be considered when assessing and treating the elderly people who underwent brain tumor resection. The results might help the rehabilitation professionals, doctors as well the caregivers of post operative patients to understand their psychological well-being and adapt appropriate measures to support them for speedy recovery as well.
Depression and Anxiety Disorders in a Sample of Saudi Persons with Brain Tumor
Global Journal of Health Science
BACKGROUND: Depression and anxiety (DA) are common in persons with brain tumor (PBT) and are associated with neurocognitive deficits. The terms DA and affective disorders are often used interchangeably in this study. Objective: This was a pilot study, conducted with the purpose of better assessing DA symptoms in association with socioeconomic and clinical characteristics in PBT. METHOD: A cross-sectional study was conducted on a sample of PBT (N = 102), recruited from a neurosurgical department. The tools employed were the Beck Depression Inventory-II (BDI-II) and the Hospital Anxiety and Depression Scale (HADS). The self-rating instruments proved feasible and reliable in screening for the severity of DA symptoms. The HADS is designed to measure the severity of anxiety and depressive symptoms in non-psychiatric hospital outpatients and does not assess the common somatic symptoms of these two disorders. The BDI-II evaluates the severity of depressive symptoms with items related to ph...
Assessment of Quality of Life of Patients with Brain Tumors
International Journal of Humanities, Social Sciences and Education, 2018
Introduction: Cancer as a disease and therapies administered for its treatment indicate that patients undergo major trauma, different from one person to another, and these individuals react differently. The aim of the study was to analyze the quality of life (QoL) and the level of depression anxiety and stress patients with brain tumours before and after psychotherapy.
Assessment and treatment of depression in the cancer patient
Journal of Psychosomatic Research, 1998
The prevalence, diagnosis, and treatment of depression in the cancer patient are reviewed. Although frequently encountered in the cancer patient population, depression often remains undiagnosed and untreated. This carries grave consequences in that depressed cancer patients experience a poorer quality of life, are less compliant with medical care, have longer hospital stays, and have higher mortality rates. Diagnostic assessment of depression in the cancer patient raises difficulties both upon phenomenological and etiological grounds. In particular, the presence of neurovegetative symptoms which may be secondary to either cancer or depression may cloud the diagnostic picture. Due to the serious consequences of unrecognized depression, a more sensitive inclusive approach to diagnosis is recommended in the clinical setting. Finally, the limited data regarding treatment of depression in patients with cancer is reviewed. This includes a discussion of both psychosocial and pharmacological interventions which are shown to alleviate depression, improve quality of life measures, improve immune function, and lengthen survival time.
Clinical neurology and neurosurgery, 2017
Psychological distress and cognitive impairment are common complications in patients with brain tumors that are associated with poor quality of life and worse prognosis. This pilot study aimed to evaluate the associations between psychological distress, subjective cognitive complaints and baseline neuropsychological performance of brain tumor patients before neurosurgery. Sixty-two patients with various brain tumors referred for routine neuropsychological assessment 2-3days before neurosurgery participated in the study. Short neuropsychological assessment battery was used to evaluate attention and executive functions, memory and verbal fluency. Presence of cognitive complaints was evaluated during neuropsychological interview using standardized symptoms checklist. Level of psychological distress was assessed using the Hospital Anxiety and Depression Scale. Various attention and executive function problems were reported by 13-58% patients; memory problems by 8-63%; language problems ...
A Biobehavioral Perspective on Depressive Symptoms in Patients With Cerebral Astrocytoma
Journal of Neuroscience Nursing, 2011
Over 51,000 individuals are diagnosed with a primary brain tumor in the United States each year, and for those with the most common type of malignant tumor, an astrocytoma, almost 75% will die within five years of diagnosis. While surgery, radiation, and chemotherapy have improved length of survival, mortality remains high, which underscores the need to understand how other factors affect the disease trajectory. Several recent studies have shown that depressive symptoms are independently associated with reduced quality of life and survival time after controlling for medial variables in patients with an astrocytoma. Thus, depressive symptoms represent a significant risk factor for adverse outcomes in this patient population.