Dopexamine Hydrochloride in Septic Shock (original) (raw)

The study examines the effects of dopexamine hydrochloride on oxygen consumption (V02) in hyperdynamic patients with septic shock. A single-cohort prospective design involved 29 postoperative patients administered dopexamine at a dosage of 2 ug/kg/min for 30 minutes. Results indicated significant increases in cardiac index (17%) and oxygen delivery (16%), with a slight increase in oxygen consumption (4% and 9%, respectively). However, the decrease in oxygen extraction ratio raised questions about the clinical significance of improved V02. The findings highlight the need for further investigations into the potential benefits of dopexamine in enhancing tissue oxygenation.