Inflammation and Insulin Resistance (original) (raw)

Developments in Diabetes and Insulin Resistance

Diabetes Care, 2006

... T Bloomgarden, MD. Zachary T. Bloomgarden, MD, is a practicing endocrinologist in New York, New York, and is affiliated with the ... Nichols and Brown (abstract 117) studied 28,335 individuals in the Kaiser Permanente Northwest Region with fasting glucose <100, 100–109, and ...

From insulin resistance to type 2 diabetes mellitus

2010

In dieser Dissertationsschrift sollten die Auswirkungen von Typ 2 Diabetes Mellitus (T2DM) und zugrundeliegender Insulinresistenz (IR) auf Kognition und Gehirnstruktur ermittelt werden. Dabei wurden Faktoren wie das Stresshormon Kortisol sowie weitere diabetesassoziierte Komponenten wie z.B. Bluthochdruck als Modifikatoren des Verhältnisses zwischen T2DM, IR und dem Gehirn untersucht. Im ersten Abschnitt der Dissertation wurden die Auswirkungen von T2DM auf Struktur und Funktion des Gehirns untersucht und verschiedene Kortisolparameter bestimmt. Im Fokus stand hierbei die Frage, inwiefern Kortisolabnormalitäten und weitere Faktoren Einfluss auf das diabetische Gehirn nehmen. Im zweiten Teil der Arbeit wurden die Auswirkungen der metabolischen Dysregulation während der Phase der IR auf Kognition und Retinalgefässe untersucht. Hierbei wurde ein potentieller vaskulärer Pfad zu den strukturellen und funktionellen Beeinträchtigungen des Gehirns vor der Entwicklung von T2DM verfolgt

Targeting & Solving Complex Insulin Resistance Based Illness

Context: Diabetes mellitus is one of the most prevalent and costly chronic diseases in the world 1-2 and native born Global South-Hispanic individuals have a higher average lifetime risk of developing diabetes 3 . The prevalent protocol to evaluate the risk of developing diabetes mellitus type II through the analyte ‗fasting blood sugar' (FBS) or ‗hemoglobin A1C' (HbA1C) has proven to be irrelevant to diagnose insulin resistance, the primary type II diabetes precursor. Because of this, medical research regarding insulin resistance must be reevaluated. Insulin resistance, when detected early, can be successfully treated with nutritional, dietary, and lifestyle changes.

Insulin Resistance Syndrome- the Sensitive IRS

2018

Insulin resistance is a prominent pathophysiologic syndrome in a plethora of metabolic disorders including obesity, prediabetes, type 2 Diabetes Mellitus (Ten et al., 2007), impaired glucose tolerance, dyslipidemia, polycystic ovary syndrome and hypercoagulability (Smith & LeRoith, 2004). It is strongly associated with obstructive sleep apnea, hypoventilation syndrome, pancreatitis, nonalcoholic fatty liver disease, steatohepatitis, cirrhosis, gall bladder disease, multiple cancers (breasts, uterus, cervix prostate, kidney, colon, esophagus, pancreas and liver), stroke, cataracts, coronary heart disease, and hypertension. It is also associated with causation of abnormal menses, infertility, polycystic ovary syndrome, osteoarthritis, phlebitis and other venous diseases. Insulin resistance is thought to be caused by intrinsic and extrinsic factors that contribute to its development. Once present, insulin resistance affects the metabolism, behavior, physical appearance and has lasting ...

Insulin levels in insulin resistance: phantom of the metabolic opera?

The Medical journal of Australia, 2006

Insulin resistance is considered a core component in the pathophysiology of the metabolic syndrome. Some clinicians measure serum insulin concentrations in the mistaken belief that they can be used to diagnose insulin resistance. Serum insulin levels are poor measures of insulin resistance. Furthermore, there is no clinical benefit in measuring insulin resistance in clinical practice. Measurements of fasting serum insulin levels should be reserved for large population-based epidemiological studies, where they can provide valuable data on the relationship of insulin sensitivity to risk factors for diabetes and cardiovascular disease. Clinicians should shift from identifying "insulin resistance" to identifying risk factors, such as fasting glucose and lipid levels, hypertension and central obesity. These proven risk factors converge within the metabolic syndrome. Individuals "at risk" of diabetes and atherosclerotic cardiac disease can be identified simply and inex...