Desmosome frequency: Experimental alteration may correlate with differential cell adhesion (original) (raw)

Journal of cell science, 1981

Abstract

Differential cell adhesion, a suggested guiding force for tissue rearrangement during embryogenesis, could be affected by desmosome frequency. A model system for studying embryonic tissue-positioning behaviour involves combining different tissues and following their rearrangements. We have previously shown that for one tissue, embryonic chick heart ventricle, direction of tissue positioning can be altered experimentally. Heart tissue precultured for 2.5 days tends to segregate internally, while tissue pre-cultured for just half a day tends to segregate externally. Also, intact fragments of tissue tend to segregate internally, while reaggregates of trypsin-disaggregated tissues tend to segregate externally. We show here that treatments that increase the tendency to internalize also increase the frequency of adherens junctions and treatments that increase the tendency to externalize decrease the frequency of junctions. An identical hierarchical ordering of the 4 experimental tissues o...

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