Giant cell tumor of tendon sheath: Cytomorphologic and radiologic findings in 41 patients (original) (raw)
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Fine Needle Aspiration Cytology of Giant Cell Tumour of Tendon Sheath
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022
Introduction: Giant Cell Tumour of Tendon Sheath (GCTTS), also known as localised nodular tenosynovitis, is a slow growing benign soft tissue tumour arising from synovium of tendon sheath, bursa or joint. Clinically, the lesions occur as skin-coloured nodules typically on the extremities. These tumours occur more frequently on the upper limbs especially hands (77%) where they form the second most common tumour following simple ganglion cyst. Aim: To describe the cytomorphologic findings in GCTTS and their histopathological features. Materials and Methods: This retrospective study was conducted at Department of Pathology, ESI Hospital, Delhi, India, in 12 diagnosed GCTTS cases for their cytological features from January 2015 to December 2017. Fine Needle Aspiration Cytology (FNAC) was performed with a 22-gauge needle attached to a 10 mL syringe. Smears were air-dried and stained with Giemsa stain. Cytomorphology of all the selected cases were analysed and descriptive statistics were ...
Comparison of cytologic features of giant-cell tumor and giant-cell tumor of tendon sheath
Diagnostic Cytopathology, 2004
The cytologic features in twelve cases of giant-cell tumor (GCT) and five cases of giant-cell tumor of tendon sheath (GCTTS) diagnosed by fine-needle aspiration cytology (FNAC) are described. All of these cases were histopathologically confirmed. The aspirates of GCT are composed of a dual population of mononucleated spindle cell and multinucleated giant cells. The peripheral adherence of giant cells to the spindle cell is the feature of diagnostic significance in GCT. In GCTTS, the aspirate consists of a polymorphic population composed of mononuclear histiocytelike cells, hemosiderin laden macrophages, foamy macrophages, and a few multinucleated giant cells. FNAC can be used as a diagnostic tool for an early and accurate detection of these two giant cell-rich lesions, since the cytologic features when evaluated in conjunction with the clinical and radiologic features are sufficiently diagnostic.
Fine-needle aspiration cytology of giant cell tumor of tendon sheath
Diagnostic Cytopathology, 2003
Giant cell tumor of tendon sheath (GCTTS) is a unique soft tissue lesion of the hands and feet. As the cytomorphological features of this lesion are rarely documented, the spectrum of cytomorphological features in 20 cases of GCTTS seen in fine-needle aspiration (FNA) smears are presented. Patients were in the 12–64-yr age group with an equal sex ratio. Fingers or thumb were the commonest site (16 cases), followed by foot (3 cases) and palm (1 case). FNA smears were cellular and composed of varying proportions of stromal and giant cells. Stromal cells showed a dispersed arrangement and were polygonal to spindle shaped. Nuclear grooves and convolutions were found in some of the stromal cells in all cases. Intranuclear cytoplasmic inclusions were occasionally seen. Polygonal cells with round nuclei and nucleoli having abundant cytoplasm, along with binucleate forms, were also found in all cases. Histological sections were available in 10 cases and corroborated the cytological features. Hemosiderin-laden macrophages (11 of 20 cases) and abundant foamy vacuolation of stromal cells (3 of 20 cases) were also observed in FNA smears. In tissue sections, both features were seen in all cases, but with a patchy distribution. The cytological features of GCTTS are uniform, and FNA cytodiagnosis is possible. Diagn. Cytopathol. 2003;29:105–110. © 2003 Wiley-Liss, Inc.
Giant cell tumor of tendon sheath: a multicentric presentation
Case Reports in Clinical Pathology, 2014
Giant cell tumor of the tendon sheath (GCTTS) is a relatively common soft tissue neoplasm arising from the tendon sheaths of upper and lower extremities. However, the incidence of GCTTS at multiple sites is not yet reported in literature which is extremely rare. Here we are reporting a case of a 21 year female presenting with slow growing, firm swellings on bilateral elbow and tendoachilis region. Fine needle aspiration was done from all the sites which revealed the features of GCTTS. This case highlights the unusual multicentric presentation of GCTTS.
European Radiology, 1997
The objective of this study was to evaluate the appearance of localized giant cell tumour of the tendon sheath (GCTTS) on unenhanced and Gd-enhanced MR images. MR images of 13 histologically proven cases of localized GCTTS were evaluated for mean size, location, homogeneity and signal intensity (SI) on both T1-and T2-weighted images, and enhancement pattern. All lesions except 1 affected young adults. On T1-and T2-weighted images, lesions showed predominantly low SI equal to or slightly higher than skeletal muscle. On Gd-enhanced T1-weighted images, strong homogeneous enhancement was seen. These findings reflect the underlying histological composition of the lesion; haemosiderin deposition in xanthoma cells, shortening T2-relaxation time, and abundant collagenous proliferation are responsible for low SI on T1-and T2-weighted images. Strong homogeneous enhancement originates from numerous proliferative capillaries in the collagenous stroma. We conclude that these characteristic MR features, together with clinical information, are a valuable diagnostic tool in offering a correct preoperative diagnosis.
Giant cell tumor of tendon sheath: An institutional experience
International Journal of Clinical and Diagnostic Pathology, 2020
Giant Cell Tumor of Tendon Sheath (GCTTS) is the second most common benign tumour affecting hand after ganglion. It more commonly affects middle aged women with index finger being the most commonly affected site. There is high propensity of recurrence following surgical excision. The objective of this study was to review all cases of GCTTS received in our department and to study the age and gender distribution, location and histological features of the same.
Giant Cell Tumor of the Tendon Sheath
JCR: Journal of Clinical Rheumatology, 2009
Background: Giant cell tumor of tendon sheath (GCTTS) is often thought of as a volar finger mass. We hypothesized that GCTTS are equally common on the dorsal and volar aspects of the hand. In addition, we hypothesized that there are no factors associated with the location (volar versus dorsal) and largest measured dimension of a GCTTS.