Moderately Preterm Children Have More Respiratory Problems during Their First 5 Years of Life Than Children Born Full Term (original) (raw)

2013, American Journal of Respiratory and Critical Care Medicine

Rationale: Pulmonary outcomes of moderate-preterm children (MP) are unknown. Objectives: To investigate the prevalence of respiratory symptoms during infancy and at preschool age of MP compared with full-term (FT) and early preterm children (EP) and to determine factors associated with respiratory symptoms of MP at school age. Methods: Prospective cohort study. Outcome variables: number of rehospitalizations caused by respiratory problems, prevalence of respiratory symptoms determined by ISAAC Questionnaires, and factors associated with respiratory symptoms determined by univariate and multivariate analyzes. Measurements and Main Results: A total of 988 MP, 551 EP, and 573 FT children were included. The number of hospitalizations caused by respiratory problems during the first year of life was doubled in MP compared with FT (6% vs. 3%; P , 0.001). At preschool age, compared with FT, MP reported more cough or wheeze during a cold (63% vs. 50%; P , 0.001); cough or wheeze without a cold (23% vs. 15%; P ¼ 0.001); nocturnal cough (33% vs. 26%; P ¼ 0.005); dyspnea (8% vs. 4%; P ¼ 0.011); and use of medication (inhaled steroids, 9% vs. 6%; P ¼ 0.042) (antibiotics, 12% vs. 7%; P ¼ 0.002). Factors associated with respiratory symptoms at 5 years among MP were respiratory problems, eczema, rehospitalization in infancy, passive smoking in infancy, family history of asthma, and higher social class. Multivariate analyzes showed the same results except for rehospitalization in infancy.

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Moderately Preterm Children Have More Respiratory Problems during Their First 5 Years of Life Than Children Born Full Term (original) (raw)

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