DNA analysis by single molecule stretching in nanofluidic biochips (original) (raw)

Abstract

Stretching single DNA molecules by confinement in nanofluidic channels has attracted a great interest during the last few years as a DNA analysis tool. We have designed and fabricated a sealed micro/nanofluidic device for DNA stretching applications, based on the use of the high throughput NanoImprint Lithography (NIL) technology combined with a conventional anodic bonding of the silicon base and

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References (27)

  1. F. Persson, J.O. Tegenfeldt, Chem. Soc. Rev. 39 (2010) 985-999.
  2. J.O. Tegenfeldt, C. Prinz, H. Cao, R.L. Huang, R.H. Austin, S.Y. Chou, E.C. Cox, J.C. Sturm, Anal. Bioanal. Chem. 378 (2004) 1678-1692.
  3. N. Douville, D. Huh, S. Takayama, Anal. Bioanal. Chem. 391 (2008) 2395-2409.
  4. J.O. Tegenfeldt, C. Prinz, H. Cao, S.Y. Chou, W. Reisner, R. Riehn, W.M. Wang, E.C. Cox, J.C. Sturm, P. Silberzan, R.H. Austin, Proc. Natl. Acad. Sci. USA 101 (30) (2004) 10979-10983.
  5. W. Reisner, K.J. Morton, R. Riehn, Y.M. Wang, Z.N. Yu, M. Rosen, J.C. Sturm, S.Y. Chou, E. Frey, R.H. Austin, Phys. Rev. Lett. 94 (2005) 196101-196104.
  6. W. Reisner, J.P. Beech, N.B. Larsen, H. Flyvberg, A. Kristensen, J.O. Tegenfeldt, Phys. Rev. Lett. 99 (4) (2007) 058302-1-058302-4.
  7. Y.M. Wang, J.O. Tegenfeldt, W. Reisner, R. Riehn, X.J. Guan, L. Guo, I. Golding, E.C. Cox, J. Sturn, R.H. Austin, Proc. Natl. Acad. Sci. USA 102 (2005) 9796-9801.
  8. R. Riehn, M.C. Lu, Y.M. Wang, S.F. Lim, E.C. Cox, R.H. Austin, Proc. Natl. Acad. Sci. USA 102 (2005) 10012-10016.
  9. K. Jo, D.M. Dhingra, T. Odijk, J.J. de Pablo, M.D. Graham, R. Runnheim, D. Forrest, D.C. Schwartz, Proc. Natl. Acad. Sci. USA 104 (2007) 2673-2678.
  10. J.T. Mannion, C.H. Reccius, J.D. Cross, H.G. Craighead, Biophys. J. 90 (2006) 4538-4545.
  11. C. Reccius, S.M. Stavis, J.T. Mannion, L.P. Walker, H.G. Craighead, Biophys. J. 95 (2008) 273-286.
  12. F. Persson, P. Utko, W. Reisner, N.B. Larsen, A. Kristensen, Nano Lett. 9 (4) (2009) 1382-1385.
  13. J.L. Perry, S.G. Kandlikar, Microfluidics Nanofluidics 2 (3) (2005) 185-193.
  14. H. Cao, Z. Yu, J. Wang, J.O. Tegenfeldt, R. Austin, E. Chen, W. Wu, S.Y. Chou, Appl. Phys. Lett. 81 (1) (2002) 174-176.
  15. W. Li, J.O. Tegenfeldt, L. Chen, R. Austin, S.Y. Chou, P.A. Kohl, J. Krotine, J. Sturn, Nanotechnology 14 (2003) 1-6.
  16. L.J. Guo, X. Cheng, S.Y. Chou, Nano Lett. 4 (1) (2004) 69-73.
  17. B. Bilenberg, S. Jacobsen, C. Pastore, T. Nielsen, S.R. Enghoff, C. Jeppenssen, V. Larsen, A. Kristensen, Jpn. J. Appl. Phys. 44 (2005) 5606-5614.
  18. B. Bilenberg, S. Jacobsen, M.S. Schmidt, L.H.D. Skjolding, P. Shi, P. Boggild, J.O. Tegenfeldt, A. Kristensen, Microelectron. Eng. 83 (2006) 1609-1612.
  19. L.H. Thamdrup, A. Klukowska, A. Kristensen, Nanotechnology 19 (2008) 125301-125307.
  20. X. Liang, K.J. Morton, R.H. Austin, S.Y. Chou, Nano Lett. 7 (12) (2007) 3774- 3780.
  21. Q. Xia, K.J. Morton, R.H. Austin, S.Y. Chou, Nano Lett. 8 (11) (2008) 3830-3833.
  22. X. Liang, S.Y. Chou, Nano Lett. 8 (5) (2008) 1472-1476.
  23. T. Maleki, S. Mohammadi, B. Ziaie, Nanotechnology 20 (2009) 105302-105308.
  24. P.G. de Gennes, Scaling Concepts in Polymer Physics, Cornell University Press, Ithaca, NY, 1979.
  25. E. Abad, S. Merino, A. Retolaza, A. Juarros, Microelectron. Eng. 85 (6) (2008) 818-821.
  26. T. Perkins, D.E. Smith, R.G. Larson, S. Chu, Science 268 (1995) 83-87.
  27. H. Cao, J.O. Tegenfeldt, R. Austin, S.Y. Chou, Appl. Phys. Lett. 81 (16) (2002) 3058-3060.