Skeletal Muscle Relaxant Activity of Aqueous Extract of Carica Papaya Leaves on Wistar Rats (original) (raw)
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Acute and Chronic Studies of the Aqueous and Ethanol Extracts of Carica Papaya Linn in Wistar Rats
In an attempt to mobilize indigenous healthcare knowledge, we carried out an acute and chronic oral toxicity study on the aqueous and ethanol leaf extracts of Carica papaya (CP) in Wistar rats. Pawpaw (Carica papaya L.)is a popular fruit tree of tropical origin. The fruits serve as fruits and vegetables worldwide. Its reported ethnomedical uses include the treatment of anemia, diabetes mellitus, intestinal helminthiasis, malaria, diarrhea, jaundice and wounds. Acute oral toxicity study of the extracts of CPup to a dose of 5gKg -1 BW was studied in mice. Sub-acute (aqueous and ethanol extract) and sub-chronic oral toxicity (aqueous only) were carried out on 18 groups of 6 ratseach, at doses of 0.25gKg -1 , .5gKg -1 and 1gKg -1 BW. Control groups received water and corn oil respectively. At the end of the experiments, rats were sacrificed and hematological parameters, plasma biochemical parameters and histopathological examination were carried out. No deaths or signs of acute oral toxicity were recorded. Observations after oral sub-acute and sub-chronic toxicity includedhypoglycemia, hypolipidemiaand hyperglycemia, increased AST, BUN values in aqueous and ethanol extract experimentations respectively. CPshowed no oral acute toxicity. Aq. Extract is hypoglycemic, hypolipidemic whereas the ethanol extract showed signs of liver and kidney toxicity at high doses, which was confirmed after histopathological examination. The aqueous extract showed lesser toxicity than the ethanol extract.
A Review Article: Pharmacological uses and Phytochemistry Studies on Carica papaya
International Journal of Pharmaceutical Sciences and Medicine
For a very long time, the papaya has been valued for both its nutritionals, and therapeutic activity. The various traditional medical systems, including Ayurveda, are well aware of the therapeutic benefits of papaya fruit and other parts. Its many portions have been described in numerous traditional literatures for various disease situations, including cold, fever, headache, swellings, gonorrhoea, itches, jaundice, eczema, asthma, chicken pox, bronchitis and whooping cough. Over the past forty years, numerous outstanding studies on biological functions and therapeutic uses have been documented, establishing it as a significant nutraceutical agent. Scientific research has been done on the Carica papaya Linn. leaf for a number of therapeutic purposes, including antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, and anti-mollusk properties. Given this, Leaves have been investigated using variation of cutting-edge approach, as well as phytoextraction of heavy metals a...
2014
Carica papaya belongs to caricaceae family and it is commonly known as 'papaya'. Carica papaya is used in ayurvedic medicines from very long time. It is used as anti-inflammatory, antioxidant, diuretic, antibacterial, abortifacient, vermifuge, hypoglycemic, antifungal activity, antihelmenthic and immunomodulatory etc. Scientific evidences suggest their versatile biological function that supports its traditional use in different diseases. Phytochemical studies shows that plant carica papaya contains mainly alkaloids carpaine, pseudocarpaine, tannins, flavnoids, carcin, gamma terpine, glycoside carposides, sugars etc. The plant has effective pharmacological activity such as anti-inflammatory, antioxidant, diuretic, antibacterial, abortifacient, hypoglycemic, antifungal, antihelmenthic and immunomodulatory, hepatoprotective and anticonvulsant activity.
A REVIEW ON PHARMACOGNOSY, PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITY OF CARICA PAPAYA (LINN.) LEAF
International Journal of Pharmaceutical Sciences and Research, 2018
Papaya (Carica papaya Linn.) is well known for its nutritional as well as medicinal value since long time. The medicinal properties of fruit and other parts of papaya are well known in the different system of traditional medicine including Ayurveda. Its various parts has been reported for various disease conditions viz. fever, swellings, jaundice, gonorrhea, bilious fever, itches, eczema, and rheumatism cold, headache, whooping cough, asthma, chicken pox, and bronchitis in various traditional literature. The various remarkable researches on biological activities and medicinal application have been reported during past four decades and established it as an important nutraceuticals agent. Carica papaya Linn. leaf has been scientifically studied for various therapeutic activities like antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, anti-molluscal etc. In view of this leaves have been explored through several advanced techniques like phyto-extraction of heavy metals, phytoremediation of particulate pollution and many others. Various studies on phytoconstituents and chemical composition of leaves have been reported in last few decades. The present review aims an exploration of pharmacognostical, phytochemical and pharmacological studies of Carica papaya Linn. leaf till now.
Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya
Journal of Wildlife and Biodiversity, 2020
Diospyros kaki L. (Ebenaceae) fruit and leaves are traditionally used for the treatment of hypertension and angina, as well as for their antithrombotic and anti-inflammatory effects. We investigated the anti-inflammatory, analgesic and antipyretic activities of Diospyros kaki L. (Ebenaceae) in order to scientifically validate its pharmacological importance. In the current study, the anti-inflammatory, analgesic and antipyretic activities of ethyl acetate (Per-1), n-butanol (Per-2) and aqueous (Per-3) fractions of a methanol extract of Persimmon leaves were tested. W istar rats weighing 190-210 g (for the anti-inflammatory assay) and male albino mice (Swiss) weighing 18-24 g (for the antipyretic and analgesic assays) were utilized as the experimental animals. The rats were separated into eight groups (for anti-inflammatory) and seven group (for antipyretic), each consisting of six rats. Each sample was treated orally and two doses: 100 and 200 mg/kg body weight were used in these experiments. The Per-3 sample at a dose of 200 mg/kg produced the highest inflammation inhibition at 59.28%. The same sample at a dose of 200 mg/kg lowered body temperature from 38°C of hyperthermia mice back to 36.65 ± 0.12°C after 120 min, close to the normal temperature (35.21 ± 0.29°C). In the tail flick model, sample Per-3 showed 67.74% highest nociception inhibition. Similar results were obtained with Acetic acid and hot-plate assay. These results confirm that the n-butanol and aqueous fractions of persimmon are active and may be used for further pharmacological screening.
Acute toxicity study of Carica papaya leaf extract in Sprague Dawley rats
academicjournals.org
Carica papaya (CP) leaves are popularly used as food and have many traditional claims for herbal medicine. The leaf extract have been proven scientifically for their efficacy as wound healing and has protective effects against gastric damage in rats. However, toxicity study of the CP leaf extract is still lacking. The present study is to investigate the acute toxicity of CP leaf extract on Sprague Dawley rats at a dose of 2000 mg/kg body weight (BW). Sighting study was conducted in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg BW. No signs of toxicity and no deaths were observed. Based on the sighting study, we selected a dose of 2000 mg/kg BW and were observed for 14 days. The study includes control and treatment group, each consisting of 5 female rats. The single oral dose of the CP leaf extract did not produce mortality or significant changes in the body weight, food and water consumption. The relative weights of the internal organs were normal. However, hemoglobin (HGB), hematocrit (HCT), red blood cell (RBC) and total protein were significantly increase indicating dehydration. Apart from triglyceride, other biochemistry parameters demonstrated no significant changes as compared to the control.
The leaves of the Carica papaya Linnaeus (CP) are the least studied portion of the plant since its fruit is well-liked for medical applications. Therefore, finding the literature that exclusively discusses the pharmacological and therapeutic benefits of CP leaves is the primary goal of this research study. Methods The medicinal and therapeutic benefits of CP leaves have been identified through research available on electronic databases like Scopus, Web of Science, Google Scholar, Pubmed, Science Direct, NIH databases, and grey literature until December 2022. Results More than 52 papers in total were searched to determine the medicinal value of the CP leaves. As a result, numerous bioactive substances have been found in the leaves, including alkaloids, glycosides, tannins, saponins, flavonoids, and others which have been intensively examined for their wide range of pharmacological properties. Conclusion Numerous studies have demonstrated that papaya leaves have potent antibacterial, antifungal, antiinflammatory, immune-modulating, hepatoprotective, hypoglycemic, anti-angiogenic, antitumor, and antiviral properties. The magical aspect of the leaves also has an antibacterial component. Additionally, it possesses antitoxins functions for the kidneys and liver and
A Mini-Review on the Phytochemistry and Pharmacology of the Plant Carica Papaya L. (Caricaceae)
Britain International of Exact Sciences (BIoEx) Journal, 2020
Medicinal plant is an important element of indigenous medical systems all over the world. The ethno botany provides a rich resource for natural drug research and development. Carica papaya is used in Traditional Medicine since a long time. Our investigations started by a search of relevant literature on the plant species. Databases such as Science direct, PubMed, Google Scholar and Scopus were used successively to retrieve the articles on C. papaya. The chemical structures of isolates compounds from this plant were drawn using ChemBioDraw Ultra 12.0 software package. Finally, bibliographical references were made using bibliographical software "Mendeley". Results show that the plant C. papaya contains various secondary metabolites, minerals and vitamins. The plant species is reported to possess various pharmacological properties like anti-oxidant, anti-inflammatory, antibacterial, anti-diabetic, anti-hyperlipidemic, larvicidal effects, etc. These pharmacological activities ...
Phytochemical Analysis of Paw-Paw (Carica Papaya) Leaves
2013
Phytochemicals are chemical compounds that occur naturally in plants. They are characterized by multilateral pharmacological activity and broad spectrum of therapeutic actions. The qualitative phytochemical analysis of Carica papaya leaves showed the presence of alkaloid, flavonoid, Saponin, Tannin and Glycosides. The qualitative test was justified by their color changes with their various reagents