Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children (original) (raw)
Related papers
The Journal of Infectious Diseases, 2001
There are no reports, to our knowledge, on the expression of Lewis (Le) antigens in Helicobacter pylori isolates from children. The aim of this study was to compare the expression of Le antigens by H. pylori isolates from children and from adults. Totals of 278 clones from 22 children with recurrent abdominal pain and 293 clones from 22 adults with ( ) or n p 10 without ( ) duodenal ulcer were studied. Expression of Le x and Le y antigens was de-n p 12 termined by ELISA, using monoclonal anti-Le antibodies. The Le phenotype of the patients was determined in gastric juice with a hemagglutination assay. Clones expressing Le x were more common in children than in adults (55.4% vs. 33.4%, respectively; ), and Le y P ! .001 was more common in adults than in children (81.6% vs. 66%, respectively; ). A trend P ! .01 analysis showed a significant decline in frequency of clones expressing Le x with age (P p ). In this community, expression of Le antigens differs in H. pylori isolates obtained from .021 children versus adults.
ASSOCIATION OF HELICOBACTER PYLORI WITH THE LEWIS ANTIGEN: A LITERATURE REVIEW (Atena Editora)
ASSOCIATION OF HELICOBACTER PYLORI WITH THE LEWIS ANTIGEN: A LITERATURE REVIEW (Atena Editora), 2023
Since the 90s, several studies have presented the probable relationship between antigens of the ABO-Lewis system and susceptibility to infections, as they end up serving as receptors or co-receptors for these microorganisms. This literary review study aimed to demonstrate the correlation between the pathogenesis of infection by Helicobacter pylori and the Lewis blood system, in order to spread knowledge of the importance of blood phenotypes to health professionals. Data collection was carried out using the PubMed and SciELO reference bases over a period of 20 years (2002 - 2022) with the terms "Blood type", "Lewis system", "ABO system'', "H. Pylori", “Helicobacter pylori.” Helicobacter pylori binds to the antigen Lewis b (Le b), rich in fucose and expressed on the surface of gastric epithelial cells. Furthermore, Le b has high affinity for BabA adhesins, one of the virulence factors of this genus of bacteria that infect humans and promote chronic inflammation and/or other gastric diseases. Since infection by this microorganism is characterized by chronicity, knowledge of its pathogenesis and correlation with all types of risk factors is an important prevention mechanism.
World journal of gastroenterology : WJG, 2006
To investigate the ABH and Lewis antigen expression in erythrocytes, saliva and gastric epithelium, as well as the association between H pylori and the presence of gastric epithelial lesions. The distribution of ABH and Lewis blood group antigens in erythrocytes, saliva and gastric mucosa of H pylori-infected gastric ulcer patients was analyzed. Forty-two patients with gastric ulcer were studied, and fifty healthy individuals were used as control group. The blood group antigens were determined by direct hemagglutination, dot-ELISA and immunohistochemical methods in erythrocytes, saliva and gastric mucosa specimens, respectively. Diagnosis for H pylori infection was performed by conventional optical microscopy and ELISA. A higher seroprevalence of IgG H pylori specific antibodies was observed in gastric ulcer patients (90%) compared to the control group (60%). We observed a significant increase of phenotypes O, A2 and Lewis b in H pylori-infected patients. The expression of these ant...
Journal of the Formosan Medical Association
The Lewis blood group system is defined by the expression of Lewis antigens, a group of fucosylated oligosaccharides, on the red blood cell membrane . Lewis antigens are also found in the human gastric epithelium , and can mediate the attachment of Helicobacter pylori to human gastric mucosa . The interaction of host Lewis antigens with H. pylori can induce changes in adherence and, thus, may possibly Background and Aims: Because of the molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood-group antigens, Lewis antigen may mediate specific H. pylori binding to surface epithelial cells in gastric mucosa. We, therefore, tested whether different Lewis antigen phenotypes have different prevalence rates of H. pylori infection, and determined the specific H. pylori-related disease entities or histologic features. Method: A total of 342 dyspeptic patients without previous anti-H. pylori therapy were enrolled after endoscopy. The Lewis phenotypes, defined as Le a-b-, Le a-b+ , Le a+b-, and Le a+b+ subtypes, were determined from the expression or absence of Lewis antigens (Le a and Le b ) on erythrocytes in each patient using monoclonal antibodies. The H. pylori-specific gastric histology was evaluated using the updated Sydney's system. Results: Of 342 patients, 233 (68.1%) had H. pylori infection. The H. pylori infection rates were significantly higher in patients with Lewis phenotypes Le a+band Le a+b+ (p < 0.05). Patients expressing the Le a antigen had a higher H. pylori infection rate than those without the Le a antigen (80.8 vs 64%, p < 0.005). In H. pylori-infected patients, patients expressing Le b antigen had a lower rate of gastroduodenal ulcers than those without Le b antigen (46.9 vs 61.4%, p < 0.05). H. pylori-positive patients who expressed the Le b antigen had higher bacterial density and inflammation severity in the gastric cardia than those who did not. Patients who expressed the Le a antigen had lower bacterial density, less chronic inflammation severity, and lower frequency of lymphoid follicles in the gastric cardia than those who did not (p < 0.05). Conclusion: The erythrocyte Lewis phenotype can be a significant host factor related to susceptibility, different histologic patterns, and clinical outcomes of H. pylori infection in Taiwan.
Fems Immunology and Medical Microbiology, 2001
In this study, we found Lewis X (Le x ) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le x IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14% and 25%). In contrast, the prevalence of anti-Le x IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover,