Peptides (original) (raw)

ChemInform

Abstract

Bioelastic materials are elastomeric polypeptides composed of repeating sequences. They are a relatively new class of polymers that may also be called elastic protein-based polymers, having their origins in repeating sequences found in the mammalian elastic protein, elastin. The most striking and longest sequence between cross-links in pig and cow is the polypentapeptide-(PPP), poly(VPGVG) or (Val1-Pro2-Gly3-Val4-Gly5)n, where n is 11 (Sandberg et al., 1985; Yeh et al, 1987). Another repeat first found in porcine elastin is a polytetrapeptide-(PTP), poly(VPGG) or (Val1-Pro2-Gly3-Gly4)n, but this repeat has not been found to occur with n greater than 2 without substitution (Sandberg et al., 1981). The next most common recurring sequence in mammalian elastin is a polyhexapeptide-(PHP), poly(APGVGV) or (Ala1-Pro2-Gly3-Val4-Gly5-Val6)n where, with but a couple of isomorphous hydrophobic residue replacements such as Val by He or Leu, n is 8 in man (Indik et al., 1987). The monomers, olig...

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