Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs (original) (raw)

Journal of Pharmaceutical and Biomedical Analysis, 1998

Abstract

A multiwavelength spectrophotometric approach has been developed to determine acid dissociation constants (pKa values) of sparingly soluble drug compounds. UV absorption spectra of the drug solution are acquired using a versatile device based on a fiber optics dip probe, a light source and a photodiode array (PDA) detector while the pH and the ionic strength of the chemical system is

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