Overnight ACTH-cortisol dose responsiveness: comparison with 24-h data, metyrapone administration and insulin-tolerance test in healthy adults (original) (raw)

Abstract

Objective-To estimate the dose-dependence of endogenous ACTH's stimulation of adrenal cortisol secretion overnight.

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (33)

  1. Clynes, M. Med. Physics. Chicago, IL.: Yearbook Publ.; 1960. Biology: applications of control system theory.
  2. Dempsher DP, Gann DS, Phair RD. A mechanistic model of ACTH-stimulated cortisol secretion. Am J Physiol. 1984; 246:R587-R596. [PubMed: 6326602]
  3. Keenan, DM.; Veldhuis, JD. Encyclopedia of Hormones. San Diego, CA.: Academic Press; 2003. Mathematical modeling of receptor-mediated interlinked systems; p. 286p. 294
  4. Veldhuis JD, Keenan DM, Pincus SM. Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev. 2008; 29:823-864. [PubMed: 18940916]
  5. Roelfsema F, Pincus SM, Veldhuis JD. Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects. J Clin Endocrinol Metab. 1998; 83:688-692. [PubMed: 9467594]
  6. Korbonits M, Bujalska I, Shimojo M, et al. Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors. J Clin Endocrinol Metab. 2001; 86:2728-2733. [PubMed: 11397878]
  7. Karl M, Lamberts SW, Koper JW, et al. Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation. Proc Assoc Am Physicians. 1996; 108:296-307. [PubMed: 8863343]
  8. DeCherney GS, Debold CR, Jackson RV, et al. Effect of ovine corticotropin-releasing hormone administered during insulin-induced hypoglycemia on plasma adrenocorticotropin and cortisol. J Clin Endocrinol Metab. 1987; 64:1211-1218. [PubMed: 3033009]
  9. Orth DN, Jackson RV, DeCherney GS. Effect of synthetic ovine corticotropin-releasing factor. Dose response of plasma adrenocorticotropin and cortisol. J Clin Invest. 1983; 71:587-595. [PubMed: 6298280]
  10. Tuchelt H, Dekker K, Bahr V, et al. Dose-response relationship between plasma ACTH and serum cortisol in the insulin-hypoglycaemia test in 25 healthy subjects and 109 patients with pituitary disease. Clin Endocrinol (Oxf). 2000; 53:301-307. [PubMed: 10971446]
  11. Parker CR Jr, Slayden SM, Azziz R, et al. Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J Clin Endocrinol Metab. 2000; 85:48-54. [PubMed: 10634362]
  12. Oelkers W, Boelke T, Bahr V. Dose-response relationships between plasma adrenocorticotropin (ACTH), cortisol, aldosterone, and 18-hydroxycorticosterone after injection of ACTH-(1-39) or human corticotropin-releasing hormone in man. J Clin Endocrinol Metab. 1988; 66:181-186. [PubMed: 2826525]
  13. Keenan DM, Roelfsema F, Veldhuis JD. Dose-response downregulation within the span of single interpulse intervals. Am J Physiol. 2010; 299:R11-R18.
  14. Keenan DM, Licinio J, Veldhuis JD. A feedback-controlled ensemble model of the stress- responsive hypothalamo-pituitary-adrenal axis. Proc Natl Acad Sci USA. 2001; 98:4028-4033. [PubMed: 11274427]
  15. Veldhuis JD, Iranmanesh A, Naftolowitz D, et al. Corticotropin secretory dynamics in humans under low glucocorticoid feedback. J Clin Endocrinol Metab. 2001; 86:5554-5563. [PubMed: 11701735]
  16. Iranmanesh A, Veldhuis JD. Hypocortisolemic clamp unmasks jointly feedforward-and feedback- dependent control of overnight ACTH secretion. Eur J Endocrinol. 2008; 159:561-568. [PubMed: 18713842]
  17. Iranmanesh A, Lizarralde G, Veldhuis JD. Coordinate activation of the corticotropic axis by insulin-induced hypoglycemia: simultaneous estimates of B-endorphin, ACTH, and cortisol secretion and disappearance in normal men. Acta Endocrinol (Copenh). 1993; 128:521-528. [PubMed: 8393257]
  18. Zar, JH. Biostatistical analysis. 3rd edition ed.. Upper Saddle River, NJ: Prentice Hall; 1996.
  19. Thomas MA, Rebar RW, LaBarbera AR, et al. Dose-response effects of exogenous pulsatile human corticotropin-releasing hormone on adrenocorticotropin, cortisol, and gonadotropin concentrations in agonadal women. J Clin Endocrinol Metab. 1991; 72:1249-1254. [PubMed: 1851183]
  20. Hensen J, Hader O, Bahr V, et al. Effects of incremental infusions of arginine vasopressin on adrenocorticotropin and cortisol secretion in man. J Clin Endocrinol Metab. 1988; 66:668-671. [PubMed: 2831245]
  21. Lambert A, Frost J, Garner C, et al. Cortisol production by dispersed guinea-pig adrenal cells; a specific, sensitive and reproducible response to ACTH....and its fragments. J Steroid Biochem. 1984; 21:157-162. [PubMed: 6090810]
  22. Nye EJ, Grice JE, Hockings GI, et al. Comparison of adrenocorticotropin (ACTH) stimulation tests and insulin hypoglycemia in normal humans: low dose, standard high dose, and 8-hour ACTH- (1-24) infusion tests. J Clin Endocrinol Metab. 1999; 84:3648-3655. [PubMed: 10523009]
  23. Gonzalbez J, Villabona C, Ramon J, et al. Establishment of reference values for standard dose short synacthen test (250 microgram), low dose short synacthen test (1 microgram) and insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in normal subjects. Clin Endocrinol (Oxf). 2000; 53:199-204. [PubMed: 10931101]
  24. Abdu TA, Elhadd TA, Neary R, et al. Comparison of the low dose short synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. J Clin Endocrinol Metab. 1999; 84:838-843. [PubMed: 10084558]
  25. Engeland WC. Functional innervation of the adrenal cortex by the splanchnic nerve. Horm Metab Res. 1998; 30:311-314. [PubMed: 9694555]
  26. Keenan DM, Roelfsema F, Carroll BJ, et al. Sex defines the age dependence of endogenous ACTH-cortisol dose responsiveness. Am J Physiol Regul Integr Comp. 2009; 297:R515-R523.
  27. Roelfsema F, van den Berg G, Frolich M, et al. Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin. J Clin Endocrinol Metab. 1993; 77:234-240. [PubMed: 8392084]
  28. Veldhuis JD, Roelfsema F, Iranmanesh a, et al. Basal, pulsatile, entropic (patterned) and spiky (staccato-like) properties of ACTH secretion: impact of age gender and body mass index. J Clin Endocrinol Metab. 2009; 94:4045-4052. [PubMed: 19755477]
  29. Vamvakopoulos NC, Chrousos GP. Hormonal regulation of human corticotropin-releasing hormone gene expression: implications for the stress response and immune/inflammatory reaction. Endocr Rev. 1994; 15:409-420. [PubMed: 7988479]
  30. Jacobson L. Hypothalamic-pituitary-adrenocortical axis regulation. Endocrinol Metab Clin North Am. 2005; 34:271-292. [PubMed: 15850842]
  31. Courtney CH, McAllister AS, McCance DR, et al. Comparison of one week 0900 h serum cortisol, low and standard dose synacthen tests with a 4 to 6 week insulin hypoglycaemia test after pituitary surgery in assessing HPA axis. Clin Endocrinol (Oxf). 2000; 53:431-436. [PubMed: 11012567]
  32. Kamrath C, Boehles H. The low-dose ACTH test does not identify mild insufficiency of the hypothalamic-pituitary-adrenal axis in children with inadequate stress response. J Pediatr Endocrinol Metab. 2010; 23:1097-1104. [PubMed: 21284322]
  33. Maghnie M, Uga E, Temporini F, et al. Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests. Eur J Endocrinol. 2005; 152:735-741. [PubMed: 15879359]