Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor
Alfons Lawen
Journal of Biological Chemistry, 1994
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THE JOURNAL OP BIOLOGICAL CHEMISTRY 0 1990 by The American Society for Biochemistry and Molecular Biology, Inc. THE MOST COMPLEX PEPTIDE SYNTHESIZING MULTIENZYME POLYPEPTIDE SO FAR DESCRIBED*
Alfons Lawen
Journal of Biological Chemistry
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Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
Peter Grün
Nature Chemistry, 2019
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A Nonribosomal System of Peptide Biosynthesis
Hans von Döhren
European Journal of Biochemistry, 1996
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Cyclosporin synthetase is a 1.4 MDa multienzyme polypeptide Re-evaluation of the molecular mass of various peptide synthetases
Alfons Lawen, Detlev Riesner
FEBS Letters, 1992
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Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products
Michael Thomas
Molecular Pharmaceutics, 2008
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Insights into an Unusual Nonribosomal Peptide Synthetase Biosynthesis
Margherita Sosio
Journal of Biological Chemistry, 2010
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NRPS toolbox for the discovery of new nonribosomal peptides and synthetases
Maude Pupin
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Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain
Xue Sherry Gao
Nature Chemical Biology, 2012
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New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products
Manuel A. Ortega
Cell chemical biology, 2016
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Prediction of substrate-specific pockets in cyclosporin synthetase
Holger Husi
FEBS Letters, 1997
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Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli
Kinya Hotta
Nature Chemical Biology, 2006
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The Multiple Carrier Model of Nonribosomal Peptide Biosynthesis at Modular Multienzymatic Templates
Joachim Vater
Journal of Biological Chemistry, 1996
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Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry †
Sylvie Garneau-tsodikova
Biochemistry, 2006
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Substrate recognition by nonribosomal peptide synthetase multi-enzymes
Sylvie Lautru
Microbiology (Reading, England), 2004
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How to tailor non-ribosomal peptide products—new clues about the structures and mechanisms of modifying enzymes
Lars-Oliver Essen
Molecular BioSystems, 2008
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Standard for Synthesis of Customized Peptides by Non-Ribosomal Peptide Synthetases
Tania Christiansen, Fanny Georgi, Lorenz Adlung, Dominik Niopek
2013
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Open-chain peptides obtained by acidic hydrolytic cleavage of cyclosporin A
R. Paroni
Biological Mass Spectrometry, 1994
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Do nonribosomal peptide synthetases occur in higher Eukaryotes?
Paolo Visca
IUBMB Life, 2007
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Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides
Martin Hahn
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Biosynthesis of cyclosporin A: partial purification and properties of a multifunctional enzyme from …
Ullrich Keller
Biochemistry
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Cell-free biosynthesis of new cyclosporins
Alfons Lawen
The Journal of Antibiotics, 1989
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Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases
Emmanuelle Schmitt
Nature communications, 2014
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The Rare Amino Acid Building Block 3-(3-furyl)-Alanine in the Formation of Non-ribosomal Peptides
Fayrouz El Maddah
Natural Product Communications, 2017
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Cyclosporines: Biosynthesis and Beyond
Alfons Lawen
Fungal Biology, 2014
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Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase
Lars-Oliver Essen
Science, 2008
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Chemical synthesis of peptides and peptide libraries
Victor Hruby
Chemical Biology the Role of Chemistry in Our Fundamental Understanding of Biology, 2008
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Generality of Peptide Cyclization Catalyzed by Isolated Thioesterase Domains of Nonribosomal Peptide Synthetases †
Dirk Schwarzer
Biochemistry, 2001
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Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions
Jennifer Stockdill
Journal of the American Chemical Society, 2010
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Structure Elucidation and Activity of Kolossin A, the D-/L- Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase
Kirtikumar B Jadhav
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Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: New Insights into the Role of Leader and Core Peptides during Biosynthesis
Julio Camarero
Chemistry - A European Journal, 2013
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Insights into an Unusual Nonribosomal Peptide Synthetase Biosynthesis: IDENTIFICATION AND CHARACTERIZATION OF THE GE81112 BIOSYNTHETIC GENE CLUSTER
sonia maffioli
Journal of Biological Chemistry, 2010
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Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
Candace HO
Nature Communications
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Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis
Robert Thai
Nucleic Acids Research, 2011
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Modification of Cyclosporin A (CS): Generation of an enolate at the sarcosine residue and reactions with electrophiles
Reto Naef
Helvetica Chimica Acta, 1993
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