Studies of interactions between platinum(II) complexes and some biologically relevant molecules (original) (raw)

2007, Bioorganic & Medicinal Chemistry

The reactions of Pt(II) complexes, cis-[Pt(NH 3 ) 2 Cl 2 ], [Pt(terpy)Cl] + , [Pt(terpy)(S-cys)] 2+ , and [Pt(terpy)(N7-guo)] 2+ , where terpy = 2,2 0 :6 0 ,2 00 -terpyridine, S-cys = L L-cysteine, and N7-guo = guanosine, with some biologically relevant ligands such as guanosine-5 0 -monophosphate (5 0 -GMP), L L-cysteine, glutathione (GSH) and some strong sulfur-containing nucleophiles such as diethyldithiocarbamate (dedtc), thiosulfate (sts), and thiourea (tu), were studied in aqueous 0.1 M Hepes at pH of 7.4 using UV-vis, stopped-flow spectrophotometry, and 1 H NMR spectroscopy.