Centrosome dynamics during the meiotic progression in the mouse oocyte (original) (raw)

The centrosome is the most important microtubule organizing centre and a major point for microtubule growth within the cell. Because of their microtubule nucleating capacity, centrosomes are responsible for many functions, such as the organization of the interphase cytoskeleton and cytoplasm and the formation of the mitotic spindle. Centrosomes are known to participate in the location of the cleavage furrow during cytokinesis (1). In this context, it is useful to note that several types of proteins including motor molecules such as kinesin and dynein , microtubule-associated proteins such as the microtubule associated protein MAPI (4), Ca/calmodulin kinase II (5), centractin and centrin (6) are associated with centrosomes.