Microfluidic-Enabled Print-to-Screen (P2S) Platform for High-Throughput Screening of Combinatorial Chemotherapy (original) (raw)

Analytical chemistry, 2015

Abstract

Since the 1960s, combination chemotherapy has been widely utilized as a standard method to treat cancer. However, due to the potentially enormous number of drug candidates and combinations, conventional identification methods of the effective drug combinations are usually associated with significantly high operational costs, low throughput screening, laborious and time-consuming procedures, and ethical concerns. In this paper, we present a low-cost, high-efficiency microfluidic print-to-screen (P2S) platform, which integrates combinatorial screening with biomolecular printing for high-throughput screening of anti-cancer drug combinations. This P2S platform provides several distinct advantages and features, including automatic combinato-rial printing, high-throughput parallel drug screening, modular disposable cartridge and biocompatibility, which can potentially speed up the entire discovery cycle of potent drug combinations. Microfluidic impact printing utilizing plug-and-play micr...

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