Effects of cola intake on fertility: a review (original) (raw)

ABSTRACT The consumption of soft drinks has increased considerably during the last decades. Among them, the cola-based preparations are possibly the refreshments with the largest sales worldwide. During the previous years, important concerns have been raised about the effects of colas on human health. In this review, we introduce the cola effects on reproduction including pregnancy miscarriages, ovulatory and menstrual disorders, and reduced semen quality. Although caffeine intoxication may be thought to play the most important role, a component of cola other than caffeine, or in combination with caffeine, may be associated with increased risk of reproductive hazards in heavy cola (> 1 L per day)-consumers. Cola discontinuation usually leads to an uneventful recovery in the most cases suggesting justification of limitations in the maximum recommended daily dose of these soft drinks. Cola is not an essential beverage, and abstaining from drinking more than 1 L per day is a minor intrusion in one’s personal life. Despite these uncertainties, this growing know- ledge may alarm the fertility risk of chronic cola intake in peoples of childbearing age.

The Effect of Caffeine Consumption on Fertilization and IVF Outcomes: A Review and Presentation of Original Data

Obstetrics Gynecology and Reproductive Sciences, 2019

Caffeine is widely consumed by both men and women but its pharmacological effects have not been well studied in the area of assisted reproduction. Various authorities indicate that caffeine consumption up to 400 mg per day is safe, but caution is advised for women who are, or are contemplating pregnancy and they should keep their intake under 200 mg per day. Our lifestyle studies at Curtin University showed adverse effects from caffeine consumption in both men and women. For men, fertilization rates were negatively associated with caffeine consumption (P<0.05) as well as IVF-related stress (P<0.005). Furthermore, caffeine negated the beneficial effect of male alcohol consumption, comprising mainly beer, on fertilization. For women, fertilization rates were negatively associated with caffeine consumption (P<0.005) and smoking history in years (P<0.001). However, our studies could not show any effect of caffeine consumption on the chance of pregnancy or miscarriage up to w...

Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies

Systematic reviews, 2016

Previous studies showed that high dose of caffeine intake may induce some specific human reproductive system diseases, even lead to infertility. In consideration of the high consumption of caffeine according to the latest population-based survey, this review is aimed to systematically review the evidence from all controlled clinical studies of caffeine intake for infertility. Relevant randomized/quasi-randomized controlled trials, non-randomized clinical studies, cohort studies, and case-control studies will be included in this review. Participants will be either those without a history of infertility who are willing to have a baby (for prospective studies) or infertile patients with confirmed diagnosis (for retrospective studies). Caffeine or caffeine-containing beverage will be observed as the exposure factor. The key outcome will be the diagnosis of infertility in participants. All relevant published/unpublished or ongoing studies will be searched from seven databases and four on...

Coffee and caffeine intake and male infertility: a systematic review

Nutrition journal, 2017

Semen quality, a predictor of male fertility, has been suggested declining worldwide. Among other life style factors, male coffee/caffeine consumption was hypothesized to influence semen parameters, but also sperm DNA integrity. To summarize available evidence, we performed a systematic review of observational studies on the relation between coffee/caffeine intake and parameters of male fertility including sperm ploidy, sperm DNA integrity, semen quality and time to pregnancy. A systematic literature search was performed up to November 2016 (MEDLINE and EMBASE). We included all observational papers that reported the relation between male coffee/caffeine intake and reproductive outcomes: 1. semen parameters, 2. sperm DNA characteristics, 3. fecundability. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included. We retrieved 28 papers reporting observational informat...

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