ChemInform Abstract: Application of Resins of the Trityl Type in the “Solid-Phase Organic Synthesis” of Thiol-Containing Compounds (original) (raw)
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Acknowledgements irst, I would like to express my heartiest thanks to my supervisor, Prof. Spyros Pandis, for entrusting me to be part of his laboratory. Without his expert guidance and valuable support most of the results presented here would have been impossible to be obtained. His patience, encouragement and immense knowledge were key motivations throughout my master studies. Most of all, I would like to thank personally Dr. Dimitris Papanastasiou, for his grateful guidance and co-operation, with whom it was a great opportunity to share problems and opinions during my master studies. Furthermore, I feel the need to express my thanks to Michael Pikridas for his support during my first steps in the field. I would also like to thank all the members of the LAQS group, especially Kalliopi Florou, David Patoulias, Christos Kaltsonoudis and Giorgos Gkatzelis, with whom it is always a pleasure to work with. Additionally, I would like to thank my close friends Michail Michailidis and Thodoris Triantafullopoulos for the continuous friendship and encouragement. In particular, I would like to thank especially Konstantinos Giannopoulos, who was always there for me and supported me throughout this process. Last but not least, I would like to thank my parents Athanasios and Panagiota, my brother Dimitri & my sister Katerina for their priceless support, love and incessant trust during all these years.
Atmospheric Chemistry and Physics Discussions, 2015
The concentration and chemical composition of the non-refractory fine particulate matter (NR-PM 1 ) and black carbon (BC) levels were measured during the summer of 2012 in the suburbs of two Greek cities, Patras and Athens, in an effort to better understand the chemical processing of particles in the high photochemical activity environment of 5 20 suggesting that under high photochemical conditions most of the OA in the Eastern Mediterranean is quite aged. The contribution of the primary sources (HOA-1 and HOA-2) was important (22 % in Patras and 33 % in Athens) but not dominant.
Medical waste management and environmental assessment in the Rio University Hospital, Western Greece
Journal of Sustainable Chemistry and Pharmacy, 2019
At this study a multi-criteria model was developed to examine the available procedures, techniques and methods of handling infectious waste in the large healthcare unit of University Regional General Hospital of Patras, Western Greece. Particularly, this study examined the: a) current legislation and Directives issued for medical waste management at Greece and among the other EU-members, b) contribution of healthcare wastes (HCW) generation rate on social and economic parameters in selected European countries, c) available procedures, techniques, and methods upon the disposal of infectious wastes at the healthcare studied, and, d) propositions for integrated management of such hazardous wastes. Specifically, the Analytic Hierarchy Process (AHP) methodology was applied under pair wise comparison matrices in two stages: 1) the scale factors and the indicators , and 2) the criteria and their sub-criteria. The assessment of these pair wise matrices included the indicators and the sub-criteria. Subsequently, two pair wise comparison matrices, upon a) the "Fulfillment of environmental objectives" indicator and b) the "Energy consumption" sub criterion, were denoted. The AHP methodology yielded good results; however there is still space of improving the environmental performance. The normalized relative weights obtained for the criteria and sub criteria motivated specific actions that have to be handled. Particularly, the results indicated a very good value in environmental management criteria due the values obtained for the commitment towards the environmental policy standards and the waste management procedures. However, further improvements on staff awareness (such as development programs to enhance sensitivity) and more green purchasing suppliers, should be further addressed.
Global Nest Journal
Recently, the fate of emerging compounds in environmentally relevant samples has attracted considerable attention. Solar semiconductor photocatalysis may offer an appealing methodology to treat such contaminants. At the same time the use of solar photocatalysis for water and wastewater disinfection is a topic well-documented in the literature. In this respect, the simultaneous degradation of synthetic estrogen 17α-ethynylestradiol (EE2) and Escherichia coli removal employing simulated solar radiation and TiO2 as the photocatalyst was investigated. In general, the more complex the water matrix is the slower E. coli removal becomes, while the presence of E. coli in the reaction mixture did not obstruct EE2 removal. Although EE2 removal occurred relatively fast, overall estrogenic activity was only partially removed. This implies that other species inherently present in the effluent and/or some photocatalytic transformation by-products may be proportionately more estrogenic than EE2. O...
Degradation of PAHs by high frequency ultrasound
Water Research, 2011
Phenanthrene Pyrene Ultrasonic treatment High frequency a b s t r a c t Polycyclic aromatic hydrocarbons (PAHs) are persistent organic compounds, which have been reported in the literature to efficiently degrade at low (e.g. 20 kHz) and moderate (e.g. 506 kHz) ultrasound frequencies. The present study focuses on degradation of naphthalene, phenanthrene, and pyrene by ultrasound at three different relatively high frequencies (i.e. 582, 862, and 1142 kHz). The experimental results indicate that for all three frequencies and power inputs !133 W phenanthrene degrades to concentrations lower than our experimental detection limit (<1 mg/L). Phenanthrene degrades significantly faster at 582 kHz than at 862 and 1142 kHz. For all three frequencies, the degradation rates per unit mass are similar for naphthalene and phenanthrene and lower for pyrene. Furthermore, naphthalene degradation requires less energy than phenanthrene, which requires less energy than pyrene under the same conditions. No hexane-extractable metabolites were identified in the solutions. ª (I.D. Manariotis). A v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / w a t r e s w a t e r r e s e a r c h 4 5 ( 2 0 1 1 ) 2 5 8 7 e2 5 9 4 0043-1354/$ e see front matter ª
Medical waste management and environmental assessment in the Rio
Sustainable Chemistry and Pharmacy, 2019
At this study a multi-criteria model was developed to examine the available procedures, techniques and methods of handling infectious waste in the large healthcare unit of University Regional General Hospital of Patras, Western Greece. Particularly, this study examined the: a) current legislation and Directives issued for medical waste management at Greece and among the other EU-members, b) contribution of healthcare wastes (HCW) generation rate on social and economic parameters in selected European countries, c) available procedures, techniques, and methods upon the disposal of infectious wastes at the healthcare studied, and, d) propositions for integrated management of such hazardous wastes. Specifically, the Analytic Hierarchy Process (AHP) methodology was applied under pair wise comparison matrices in two stages: 1) the scale factors and the indicators , and 2) the criteria and their sub-criteria. The assessment of these pair wise matrices included the indicators and the sub-criteria. Subsequently, two pair wise comparison matrices, upon a) the "Fulfillment of environmental objectives" indicator and b) the "Energy consumption" sub criterion, were denoted. The AHP methodology yielded good results; however there is still space of improving the environmental performance. The normalized relative weights obtained for the criteria and sub criteria motivated specific actions that have to be handled. Particularly, the results indicated a very good value in environmental management criteria due the values obtained for the commitment towards the environmental policy standards and the waste management procedures. However, further improvements on staff awareness (such as development programs to enhance sensitivity) and more green purchasing suppliers, should be further addressed.
Two new diastereomeric lignan amides (4 and 5) serving as dimeric caffeic acid-L-DOPA hybrids were synthesized. The synthesis involved the FeCl 3-mediated phenol oxidative coupling of methyl caffeate to afford trans-diester 1a as a mixture of enantiomers, protection of the catechol units, regioselective saponification, coupling with a suitably protected L-DOPA derivative, separation of the two diastereomers thus obtained by flash column chromatography and finally global chemoselective deprotection of the cat-echol units. The effect of hybrids 4 and 5 and related compounds on the proliferation of two breast cancer cell lines with different metastatic potential and estrogen receptor status (MDA-MB-231 and MCF-7) and of one epithelial lung cancer cell line, namely A-549, was evaluated for concentrations ranging from 1 to 256 lM and periods of treatment of 24, 48 and 72 h. Both hybrids showed interesting and almost equipo-tent antiproliferative activities (IC 50 64–70 lM) for the MDA-MB-231 cell line after 24–48 h of treatment, but they were more selective and much more potent (IC 50 4–16 lM) for the MCF-7 cells after 48 h of treatment. The highest activity for both hybrids and both breast cancer lines was observed after 72 h of treatment (IC 50 1–2 lM), probably as the result of slow hydrolysis of their methyl ester functions.