Similarities between Somatic Cells Overexpressing the mos Oncogene and Oocytes during Meiotic lnterphase1 (original) (raw)

2000

Abstract

The mos protooncogene encodes a serine/threonine kinase and is a key regulator of oocyte meiotic maturation. After acute infedion of Swiss3T3 cells with virus containing the v-mos oncogene, cells expressing high levels of v-Mos round up and detach from the monolayer (floating cells), while cells that remain attached express 10-fold lower levels of v-Mos and are transformed. The floating cells

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