HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (original) (raw)

Abstract

he IRP/IRE regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. Iron-responsive elements (IREs) are cis-acting regulatory motifs present in mRNAs that encode for proteins involved in iron metabolism. They function as binding sites for two related trans-acting factors, namely the iron regulatory proteins (IRP1 and IRP2). Among the cis-acting oligonucleotide patterns, the IRE is one of the best characterized. It is defined by a combination of RNA sequence and structure. However, currently available programs to predict IREs do not show a satisfactory level of sensitivity and fail to detect functional IREs. Here, we report an improved software for the prediction of IREs implemented as a user-friendly web-server tool. The SIREs web-server uses a simple data input interface and provides structure analysis, predicted RNA folds, folding energy data and an overall quality flag based on properties of well...

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