Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population (original) (raw)

This research investigates the association between genetic polymorphisms in the aryl hydrocarbon receptor (AHR) and lung cancer susceptibility among smokers in a Chinese population. Through a case-control study involving 500 lung cancer patients and 517 controls, significant associations were found with polymorphisms rs2158041 and rs7811989, as well as a notable interaction between polymorphism rs2066853 and smoking intensity. These findings suggest that AHR genetic variations may influence lung cancer risk, highlighting the importance of gene-environment interactions in cancer etiology.