In vivo and in vitro induction of ‘tissue’ transglutaminase in rat hepatocytes by retinoic acid (original) (raw)

This research investigates the induction of tissue transglutaminase (tTG) in rat hepatocytes via retinoic acid (RA) treatment both in vivo and in vitro. Findings reveal elevated tTG levels in hepatocytes isolated from RA-treated rats compared to controls, indicating that RA stimulates tTG expression, despite evidence suggesting that this form of the enzyme may be inactive. The localization of tTG and its association with apoptotic cellular features were analyzed, providing insights into the role of RA in modulating hepatocyte biochemistry and potential implications for liver metabolism.